Structure-function correlations using scanning laser polarimetry in primary angle-closure glaucoma and primary open-angle glaucoma.
Structure-function correlations using scanning laser polarimetry in primary angle-closure glaucoma and primary open-angle glaucoma.
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DOI：
10.1016/j.ajo.2009.12.007
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发表时间：
2010-05
影响因子：
4.2
通讯作者：
Cheng, Ching-Yu
中科院分区：
文献类型：
--
作者：
Lee, Pei-Jung;Liu, Catherine Jui-Ling;Wojciechowski, Robert;Bailey-Wilson, Joan E.;Cheng, Ching-Yu
评估原发性开角型青光眼 (POAG) 和原发性闭角型青光眼 (PACG) 中扫描激光偏振仪 (SLP) 测量的视网膜神经纤维层 (RNFL) 厚度与视野 (VF) 敏感性之间的相关性。前瞻性、比较性、观察性病例系列 2005 年 8 月至 2006 年 7 月期间，在台北荣民总医院使用带有可变角膜补偿的 SLP（GDx VCC）和 Humphrey VF 分析仪对 50 名 POAG 患者和 56 名 PACG 患者进行了检查。 RNFL 厚度和 VF 敏感性之间的相关性以分贝 (dB) 和 1/Lambert (L) 量表的平均敏感性 (MS) 表示，通过 Spearman 等级相关系数 (rs) 和多元中值回归模型（伪 R2）估计。这些相关性是在全球范围内以及六个 RNFL 部门及其相应的 VF 区域中确定的。 RNFL厚度与MS（单位dB）之间的相关性在PACG组中（rs = 0.38，P = 0.004，伪R2 = 0.17）弱于POAG组（rs = 0.51，P <0.001，伪R2 = 0.31），但相关幅度差异不显着（P = 0.42）。经Bonferroni校正后，结构-功能相关性显着POAG 组的颞上 (rs = 0.62)、鼻上 (rs = 0.56)、鼻下 (rs = 0.53) 和颞下 (rs = 0.50) 区域（均 P <0.001），而 PACG 组仅在颞上 (rs = 0.53) 和颞下 (rs = 0.48) 区域显着（均 P <0.001）。当 MS 以 1/L 刻度表示时，结果相似。使用 SLP，POAG 和 PACG 眼都具有中等的结构功能相关性。与 POAG 眼相比，PACG 眼中具有显着结构功能相关性的 RNFL 区域较少。
To assess the correlations between retinal nerve fiber layer (RNFL) thickness measured with scanning laser polarimetry (SLP) and visual field (VF) sensitivity in primary open angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Prospective, comparative, observational cases series Fifty patients with POAG and 56 with PACG were examined using SLP with variable corneal compensation (GDx VCC) and Humphrey VF analyzer between August 2005 and July 2006 at Taipei Veterans General Hospital. Correlations between RNFL thickness and VF sensitivity, expressed as mean sensitivity (MS) in both decibel (dB) and 1/Lambert (L) scales, were estimated by Spearman's rank correlation coefficient (rs) and multivariate median regression models (pseudo R2). The correlations were determined globally and for six RNFL sectors and their corresponding VF regions. The correlation between RNFL thickness and MS (in dB) was weaker in the PACG group (rs = 0.38, P = 0.004, pseudo R2 = 0.17) than in the POAG group (rs = 0.51, P <0.001, pseudo R2 = 0.31), but the difference in the magnitude of correlation was not significant (P = 0.42).With Bonferroni correction, the structure-function correlation was significant in the superotemporal (rs = 0.62), superonasal (rs = 0.56), inferonasal (rs = 0.53), and inferotemporal (rs = 0.50) sectors in the POAG group (all P <0.001), while it was significant only in the superotemporal (rs = 0.53) and inferotemporal (rs = 0.48) sectors in the PACG group (both P <0.001). The results were similar when MS was expressed as 1/L scale. Both POAG and PACG eyes had moderate structure-function correlations using SLP. Compared to eyes with POAG, fewer RNFL sectors have significant structure-function correlations in eyes with PACG.
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DOI：
10.1111/j.1600-0420.2006.00655.x
发表时间：
2006-06-01
期刊：
ACTA OPHTHALMOLOGICA SCANDINAVICA
影响因子：
--
作者：
Da Pozzo, Stefano;Iacono, Pierluigi;Ravalico, Giuseppe
通讯作者：
Ravalico, Giuseppe
影响因子：
4.4
作者：
Cense, B;Chen, TC;de Boer, JF
通讯作者：
de Boer, JF
影响因子：
4.4
作者：
Reus, NJ;Lemij, HG
通讯作者：
Lemij, HG
影响因子：
4.1
作者：
Foster, PJ;Buhrmann, R;Johnson, GJ
通讯作者：
Johnson, GJ
影响因子：
4.4
作者：
Leung, CKS;Chong, KKL;Yung, WH
通讯作者：
Yung, WH