Theta phase precession of grid and place cell firing in open environments.
Theta phase precession of grid and place cell firing in open environments.
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DOI：
10.1098/rstb.2012.0532
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发表时间：
2014-02-05
期刊：
影响因子：
--
通讯作者：
Burgess N
中科院分区：
文献类型：
--
作者：
Jeewajee A;Barry C;Douchamps V;Manson D;Lever C;Burgess N
啮齿动物海马结构中的位置和网格细胞倾向于在相对于局部场电位θ节律的连续较早阶段发射尖峰，因为动物在线性轨道上穿过细胞的发射场。然而，这种“相位进动”的影响是不太好的特点，在觅食过程中，在二维开放的领域环境。在这里，我们将通过射击场的跑步映射到单位圆上，以汇集来自多个跑步的数据。我们问的7个行为和生理变量显示最好的循环线性相关性与θ阶段的尖峰从位置细胞在海马CA1区和网格细胞从内侧内嗅皮层的浅层。最好的相关性是投射到动物当前运行方向上的射击场峰值的距离。这是显着强于其他相关性，如瞬时发射率和时间在现场，但类似的强度与其他措施的距离通过射击场。相位进动是更强的地方细胞比网格细胞的整体，和强大的相位进动被认为是通过射击场周边的遍历（虽然略低于通过中心的遍历），符合相位编码的位移沿着电流方向。动物前方或后方的位置场距离的这种类型的相位编码对于允许在导航期间计算目标方向可能是有用的。
Place and grid cells in the rodent hippocampal formation tend to fire spikes at successively earlier phases relative to the local field potential theta rhythm as the animal runs through the cell's firing field on a linear track. However, this ‘phase precession’ effect is less well characterized during foraging in two-dimensional open field environments. Here, we mapped runs through the firing fields onto a unit circle to pool data from multiple runs. We asked which of seven behavioural and physiological variables show the best circular–linear correlation with the theta phase of spikes from place cells in hippocampal area CA1 and from grid cells from superficial layers of medial entorhinal cortex. The best correlate was the distance to the firing field peak projected onto the animal's current running direction. This was significantly stronger than other correlates, such as instantaneous firing rate and time-in-field, but similar in strength to correlates with other measures of distance travelled through the firing field. Phase precession was stronger in place cells than grid cells overall, and robust phase precession was seen in traversals through firing field peripheries (although somewhat less than in traversals through the centre), consistent with phase coding of displacement along the current direction. This type of phase coding, of place field distance ahead of or behind the animal, may be useful for allowing calculation of goal directions during navigation.
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theta修饰的大鼠海马形成中的划分细胞。
DOI：
10.1523/jneurosci.2635-04.2004
发表时间：
2004-09-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cacucci F;Lever C;Wills TJ;Burgess N;O'Keefe J
通讯作者：
O'Keefe J
DOI：
10.1523/jneurosci.2862-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fenton AA;Kao HY;Neymotin SA;Olypher A;Vayntrub Y;Lytton WW;Ludvig N
通讯作者：
Ludvig N
影响因子：
3.5
作者：
通讯作者：
--
DOI：
10.1073/pnas.95.6.3182
发表时间：
1998-03-17
影响因子：
11.1
作者：
Fenton, AA;Muller, RU
通讯作者：
Muller, RU
影响因子：
3.5
作者：
Hasselmo, Michael E.
通讯作者：
Hasselmo, Michael E.