Markers of kidney tubular and interstitial injury and function among sugarcane workers with cross-harvest serum creatinine elevation.
Markers of kidney tubular and interstitial injury and function among sugarcane workers with cross-harvest serum creatinine elevation.
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DOI：
10.1136/oemed-2021-107989
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发表时间：
2022-06
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
作者：
血清肌酐（SCr）是肾损伤的常规标志物，但也会随着脱水和肌肉工作而增加。本研究旨在阐明非传统来源慢性肾脏病（CKDnt）高危工人在长期热应激期间SCr增加是否与肾小管和间质损伤和功能的更特异性标志物相关。对30名SCr升高≥0.3 mg/dL的工人（例）采集前后的尿单核细胞趋化蛋白-1（MCP-1）、肾损伤分子-1（KIM-1）、钙结合蛋白、谷胱甘肽S-转移酶-π（GST-π）、凝集素、白细胞介素18和白蛋白、钾排泄分数（FEK）、血红蛋白、血清钾、铁蛋白和促红细胞生成素进行了测定，53名SCr稳定的工人（对照组）。尿MCP-1（差异交叉采集趋势p <0.001）、KIM-1（p=0.002）、钙结合蛋白（p= 0.02）、GST-π（p=0.04）、白蛋白（p=0.001）和FEK（p<0.001）在病例中升高，而血液血红蛋白（p<0.001）和血清促红细胞生成素（p<0.001）降低。随着SCr在整个收获季节的增加，肾小管和间质损伤和功能的几个标志物发生了变化，支持使用SCr作为经常暴露于热应激的体力活动工人肾损伤的指标。类似于此处描述的重复损伤，以及在剧烈和高温条件下持续工作，损伤标志物类似升高，可能会恶化并可能引发CKDnt。
Serum creatinine (SCr) is a routine marker of kidney injury but also increases with dehydration and muscular work. This study was to elucidate whether increase in SCr is associated with more specific markers of kidney tubular and interstitial injury and function, during prolonged heat stress among workers at high risk of chronic kidney disease of non-traditional origin (CKDnt). Urine monocyte chemoattractant protein-1 (MCP-1), kidney injury molecule-1 (KIM-1), calbindin, glutathione S-transferase-π (GST-π), clusterin, interleukin 18 and albumin, fractional excretion of potassium (FEK), blood haemoglobin, serum potassium, ferritin and erythropoietin were measured before and after harvest in a sample of 30 workers with a ≥0.3 mg/dL SCr increase across harvest (cases), and 53 workers with stable SCr (controls). Urine MCP-1 (p for differential cross-harvest trend <0.001), KIM-1 (p=0.002), calbindin (p=0.02), GST-π (p=0.04), albumin (p=0.001) and FEK (p<0.001) increased in cases, whereas blood haemoglobin (p<0.001) and serum erythropoietin (p<0.001) decreased. Several markers of tubular and interstitial injury and function changed as SCr increased across a harvest season, supporting the use of SCr as an indicator of kidney injury in physically active workers regularly exposed to heat stress. Repeated injury similar to that described here, and continued work under strenuous and hot conditions with similarly elevated injury markers is likely to worsen and possibly initiate CKDnt.
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影响因子：
2.3
作者：
Mansour SG;Puthumana J;Coca SG;Gentry M;Parikh CR
通讯作者：
Parikh CR
DOI：
10.1053/j.ajkd.2017.01.045
发表时间：
2017-08
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Mansour SG;Verma G;Pata RW;Martin TG;Perazella MA;Parikh CR
通讯作者：
Parikh CR
影响因子：
6
作者：
Phanish MK;Chapman AN;Yates S;Price R;Hendry BM;Roderick PJ;Dockrell MEC
通讯作者：
Dockrell MEC
DOI：
10.2215/cjn.08580813
发表时间：
2015-06-01
影响因子：
9.8
作者：
Palmer, Biff F.
通讯作者：
Palmer, Biff F.
影响因子：
6.1
作者：
Artunc, Ferruh;Risler, Teut
通讯作者：
Risler, Teut