DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.
DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.
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DOI：
10.1016/j.neuron.2009.09.027
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发表时间：
2009-11-25
期刊：
影响因子：
16.2
通讯作者：
Burgess, Robert W.
中科院分区：
文献类型：
--
作者：
Fuerst, Peter G.;Bruce, Freyja;Tian, Miao;Wei, Wei;Elstrott, Justin;Feller, Maria B.;Erskine, Lynda;Singer, Joshua H.;Burgess, Robert W.
DSCAM和DSCAM-LIKE 1（DSCAML 1）提供不同的神经发育功能，包括轴突导向，突触粘附和自我回避，这取决于物种，细胞类型和研究的基因家族成员。我们研究了DSCAM和DSCAML 1在发育中的小鼠视网膜中的功能。除了无长突细胞的子集，Dscam在大多数视网膜神经节细胞（RGC）中表达。在Dscam−/−小鼠中，RGCs具有束状树突和团块状细胞体，表明其在自我回避中的作用。Dscaml 1在视杆回路中表达，缺乏Dscaml 1的小鼠具有束状视杆双极细胞树突和聚集的AII无长突细胞体，也表明在自我回避中的作用。Dscam或Dscaml 1突变体视网膜中的神经元在内网状层的突触板层中适当地分层其过程，并且在缺乏Dscaml 1的小鼠中在杆电路中形成功能性突触。因此，DSCAM和DSCAML 1在自我回避中的功能相似，并且对于小鼠视网膜中的突触特异性不是必需的。
DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental functions, including axon guidance, synaptic adhesion, and self-avoidance, depending on the species, cell type, and gene family member studied. We examined the function of DSCAM and DSCAML1 in the developing mouse retina. In addition to a subset of amacrine cells, Dscam was expressed in most retinal ganglion cells (RGCs). RGCs had fasciculated dendrites and clumped cell bodies in Dscam−/− mice, suggesting a role in self-avoidance. Dscaml1 was expressed in the rod circuit, and mice lacking Dscaml1 had fasciculated rod bipolar cell dendrites and clumped AII amacrine cell bodies, also indicating a role in self-avoidance. Neurons in Dscam or Dscaml1 mutant retinas stratified their processes appropriately in synaptic laminae in the inner plexiform layer, and functional synapses formed in the rod circuit in mice lacking Dscaml1. Therefore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic specificity in the mouse retina.
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DOI：
10.1073/pnas.030413497
发表时间：
2000-02-29
影响因子：
11.1
作者：
Rockhill, RL;Euler, T;Masland, RH
通讯作者：
Masland, RH
DOI：
10.1101/sqb.2004.69.485
发表时间：
2004-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
Neves, G;Chess, A
通讯作者：
Chess, A
DOI：
10.1006/bbrc.2001.5214
发表时间：
2001-07-20
影响因子：
3.1
作者：
Agarwala, KL;Ganesh, S;Yamakawa, K
通讯作者：
Yamakawa, K
影响因子：
64.5
作者：
Matthews, Benjamin J.;Kim, Michelle E.;Grueber, Wesley B.
通讯作者：
Grueber, Wesley B.
影响因子：
64.8
作者：
Millard, S. Sean;Flanagan, John J.;Zipursky, S. Lawrence
通讯作者：
Zipursky, S. Lawrence