Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.
Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.
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DOI：
10.1111/jne.12051
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发表时间：
2013-08
影响因子：
3.2
通讯作者：
Stern JE
中科院分区：
文献类型：
--
作者：
Brown CH;Bains JS;Ludwig M;Stern JE
下丘脑视上核和室旁核含有大细胞神经分泌细胞（MNCs），它们投射到垂体后叶，在那里它们分泌催产素或加压素（抗利尿激素）进入循环。催产素对分娩很重要，对哺乳期间的乳汁排出也很重要。加压素主要促进肾脏中的水重吸收以维持体液平衡，但也增加血管收缩。催产素和加压素分泌的概况主要由细胞体处起始的动作电位的模式决定。虽然人们早就知道跨国公司的活动取决于传递生殖、渗透压和心血管状态信息的传入输入，但最近人们清楚地发现，活动严重依赖于神经胶质细胞的局部调节以及跨国公司本身的内在调节。在这里，我们提供了一个概述，在我们的理解如何内在和当地的外在机制整合与传入输入产生适当的生理调节催产素和加压素MNC活动的最新进展。
The hypothalamic supraoptic and paraventricular nucleus contain magnocellular neurosecretory cells (MNCs) that project to the posterior pituitary gland where they secrete either oxytocin or vasopressin (the anti-diuretic hormone) into the circulation. Oxytocin is important for delivery at birth and is essential for milk ejection during suckling. Vasopressin primarily promotes water reabsorption in the kidney to maintain body fluid balance, but also increases vasoconstriction. The profile of oxytocin and vasopressin secretion is principally determined by the pattern of action potentials initiated at the cell bodies. While it has long been known that the activity of MNCs depends upon afferent inputs that relay information on reproductive, osmotic and cardiovascular status, it has recently become clear that activity depends critically on local regulation by glial cells, as well as intrinsic regulation by the MNCs themselves. Here, we provide an overview of recent advances in our understanding of how intrinsic and local extrinsic mechanisms integrate with afferent inputs to generate appropriate physiological regulation of oxytocin and vasopressin MNC activity.
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影响因子：
2.5
作者：
Boudaba, C;Schrader, LA;Tasker, JG
通讯作者：
Tasker, JG
影响因子：
3.2
作者：
Boudaba, C;Di, S;Tasker, JG
通讯作者：
Tasker, JG
DOI：
10.1152/ajpendo.1998.274.3.e453
发表时间：
1998-03-01
影响因子：
5.1
作者：
Bealer, SL;Crowley, WR
通讯作者：
Crowley, WR
影响因子：
4
作者：
ANTONIJEVIC, IA;DOUGLAS, AJ;RUSSELL, JA
通讯作者：
RUSSELL, JA
影响因子：
4.8
作者：
Bealer, SL;Crowley, WR
通讯作者：
Crowley, WR