NK cells improve control of friend virus infection in mice persistently infected with murine cytomegalovirus.
NK cells improve control of friend virus infection in mice persistently infected with murine cytomegalovirus.
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DOI：
10.1186/1742-4690-10-58
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发表时间：
2013-06-05
期刊：
影响因子：
3.3
通讯作者：
Kraft AR
中科院分区：
文献类型：
--
作者：
Francois S;Peng J;Schwarz T;Duppach J;Gibbert K;Dittmer U;Kraft AR
HIV患者与巨细胞病毒(CMV)的混合感染与加速艾滋病进展和CMV终末器官疾病有关。另一方面，最近研究表明，持续的巨细胞病毒感染可以减少肿瘤复发，防止致命的细菌感染。持续巨细胞病毒感染对急性逆转录病毒重叠感染结局的影响尚不清楚。在这里，我们表明，持续的小鼠巨细胞病毒(MCMV)感染令人惊讶地赋予小鼠对主要朋友逆转录病毒感染(FV)的更高抵抗力。在初次FV重叠感染过程中，MCMV感染小鼠的Fv滴度降低，Fv特异性CD8T细胞应答增强。在持续感染MCMV的小鼠中，NK细胞在FV感染后产生更高数量的IFNGamma，这表明这些细胞参与了保护作用。在FV重叠感染期间，NK1.1+细胞的耗尽或IFNGamma的中和取消了MCMV介导的效应。我们的数据首次证明，持续的CMV感染可以诱导持久的NK细胞反应，从而增强对原发逆转录病毒感染的免疫力。据我们所知，研究原发HIV感染的研究还没有分析巨细胞病毒血清阳性在这些患者中的作用。我们的观察表明，巨细胞病毒血清阳性个体中的NK细胞可能有助于控制原发HIV感染。
Co-infection of HIV patients with cytomegalovirus (CMV) is associated with enhanced AIDS progression and CMV end-organ diseases. On the other hand, persistent CMV infection has recently been shown to decrease tumor relapse and protect against lethal bacterial infection. The influence of persistent CMV on the outcome of an acute retroviral superinfection is still unknown. Here we show that a persistent murine CMV (mCMV) infection surprisingly confers higher resistance to a primary Friend retrovirus infection (FV) of mice. Decreased FV titers and augmented FV-specific CD8 T-cell responses were found in mCMV infected mice during primary FV superinfection. NK cells produced higher amounts of IFNgamma after FV infection of persistently mCMV infected mice suggesting that these cells were involved in the ‘protective’ effect. Depletion of NK1.1+ cells or neutralization of IFNgamma during FV superinfection abrogated the mCMV-mediated effect. Our data demonstrate for the first time that a persistent CMV infection induces long-lasting NK cell responses that can enhance immunity to primary retroviral infections. To our knowledge, studies investigating primary HIV infection have not analyzed the role of the CMV seropositivity in these patients. Our observations suggest that NK cells in CMV seropositive individuals might contribute to the control of primary HIV infection.
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影响因子：
5.4
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