The co-existence of geriatric depression and amnestic mild cognitive impairment detrimentally affect gray matter volumes: voxel-based morphometry study.
The co-existence of geriatric depression and amnestic mild cognitive impairment detrimentally affect gray matter volumes: voxel-based morphometry study.
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老年抑郁症和遗忘性轻度认知障碍的共存对灰质体积产生不利影响：基于体素的形态测量研究
DOI：
10.1016/j.bbr.2012.08.007
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发表时间：
2012-12-01
影响因子：
2.7
通讯作者：
Goveas, Joseph S.
中科院分区：
文献类型：
--
作者：
Xie, Chunming;Li, Wenjun;Chen, Gang;Ward, B. Douglas;Franczak, Malgorzata B.;Jones, Jennifer L.;Antuono, Piero G.;Li, Shi-Jiang;Goveas, Joseph S.
关键词：
虽然晚年抑郁症（LLD）和遗忘型轻度认知障碍（aMCI）单独或联合与阿尔茨海默病（AD）发病风险增加相关，但这种联系的神经生物学机制尚不清楚。我们在72名60岁及以上身体健康的参与者中检查了LLD和aMCI对灰质（GM）体积的主要影响和交互影响。参与者被分为正常对照组、认知正常抑郁组、非抑郁aMCI组和抑郁aMCI组。优化的基于体素的形态测定法估计GM体积。分析了LLD和aMCI、抑郁症状和情景记忆缺陷对GM体积的主效应和交互效应。虽然情绪调节电路结构中的GM体积减少与抑郁症相关，但对各种认知表现至关重要的区域中的GM萎缩与aMCI相关。LLD-aMCI相互作用与AD相关脑结构的广泛皮质下和皮质GM体积损失相关。情景记忆缺陷和抑郁症状严重程度之间的相互作用与右额下回/前额叶和左额内侧回簇的体积损失相关。我们的研究结果表明，这些临床表型的共存是一个潜在的标志，为AD的高风险。
While late-life depression (LLD) and amnestic mild cognitive impairment (aMCI), alone and in combination, is associated with an increased risk of incident Alzheimer’s disease (AD), the neurobiological mechanisms of this link are unclear. We examined the main and interactive effects of LLD and aMCI on the gray matter (GM) volumes in seventy-two physically healthy participants aged 60 and older. Participants were separated into normal controls, cognitively normal depressed, non-depressed aMCI, and depressed aMCI groups. Optimized voxel-based morphometry estimated GM volumes. The main and interactive effects of LLD and aMCI, and of depressive symptoms and episodic memory deficits on the GM volumes were analyzed. While decreased GM volumes in the mood regulating circuitry structures were associated with depression, GM atrophy in regions essential for various cognitive performance were related to aMCI. LLD-aMCI interactions were associated with widespread subcortical and cortical GM volume loss of brain structures implicated in AD. The interactions between episodic memory deficits and depressive symptom severity are associated with volume loss in right inferior frontal gyrus/anterior insula and left medial frontal gyrus clusters. Our findings suggest that the co-existence of these clinical phenotypes is a potential marker for higher risk of AD.
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影响因子：
--
作者：
Kumar A;Kepe V;Barrio JR;Siddarth P;Manoukian V;Elderkin-Thompson V;Small GW
通讯作者：
Small GW
影响因子：
4
作者：
Gunning, Faith M.;Cheng, Janice;Murphy, Christopher F.;Kanellopoulos, Dora;Acuna, Jessica;Hoptman, Matthew J.;Klimstra, Sibel;Morimoto, Shizuko;Weinberg, James;Alexopoulos, George S.
通讯作者：
Alexopoulos, George S.
DOI：
10.3233/jad-2012-112009
发表时间：
2012
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Geerlings MI;Brickman AM;Schupf N;Devanand DP;Luchsinger JA;Mayeux R;Small SA
通讯作者：
Small SA
影响因子：
--
作者：
Gomar, Jesus J.;Bobes-Bascaran, Maria T.;Goldberg, Terry E.
通讯作者：
Goldberg, Terry E.
DOI：
10.1111/j.1532-5415.2011.03365.x
发表时间：
2011-05-01
影响因子：
6.3
作者：
Brodaty, Henry;Breteler, Monique M. B.;De Strooper, Bart
通讯作者：
De Strooper, Bart