Protein binding in patients with late-life depression.
Protein binding in patients with late-life depression.
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DOI：
10.1001/archgenpsychiatry.2011.122
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发表时间：
2011-11
影响因子：
--
通讯作者：
Small GW
中科院分区：
文献类型：
--
作者：
Kumar A;Kepe V;Barrio JR;Siddarth P;Manoukian V;Elderkin-Thompson V;Small GW
抑郁症已被确定为痴呆症的危险因素和前驱症状。常见的神经生物学机制可能是这种临床和现象学重叠的基础。使用 2-(1-{6-[(2-[18F]氟乙基)(甲基)-氨基]-2-萘基}亚乙基)丙二腈 ([18F]FDDNP) 正电子发射断层扫描检查和比较被诊断患有晚年重度抑郁症 (MDD) 的患者和健康对照个体关键大脑区域的蛋白质（淀粉样蛋白和 tau 蛋白）结合。使用正电子发射断层扫描的横断面神经影像研究。加州大学洛杉矶分校。我们的样本包括 20 名被诊断为 MDD 的患者和 19 名年龄、性别和教育水平相当的健康对照者。感兴趣区域的相对分布体积被用作所有研究参与者中[18F]FDDNP结合的量度。与对照组相比，MDD 组的 [18F]FDDNP 结合总体上以及后扣带回和外侧颞区显着更高。这些发现表明，与关键大脑区域较高蛋白质负荷相关的神经元损伤可能为晚年 MDD 的病理生理表现提供了一种机制，并对老年人抑郁症的治疗具有影响。
Depression has been identified as a risk factor and a prodrome of dementia. Common neurobiological mechanisms may underlie this clinical and phenomenologic overlap. To examine and compare protein (amyloid and tau) binding in critical brain regions in patients diagnosed as having late-life major depressive disorder (MDD) and healthy control individuals using 2-(1-{6-[(2-[18F]fluoroethyl) (methyl)-amino]-2-naphthyl}ethylidene) malononitrile ([18F]FDDNP) positron emission tomography. A cross-section neuroimaging study using positron emission tomography. University of California, Los Angeles. Our samples comprised 20 patients diagnosed as having MDD and 19 healthy control individuals of comparable age, sex, and educational level. Relative distribution volume in regions of interest was used as the measure of [18F]FDDNP binding in all study participants. When compared with controls, [18F]FDDNP binding was significantly higher overall and in the posterior cingulate and lateral temporal regions in the MDD group. These findings suggest that neuronal injury associated with higher protein load in critical brain regions might provide a mechanism in the pathophysiologic manifestation of MDD in late life and have implications for the therapeutics of depression in elderly individuals.
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影响因子：
7.2
作者：
Blasko, Imrich;Kemmler, Georg;Fischer, Peter
通讯作者：
Fischer, Peter
影响因子：
2.1
作者：
Butters, Meryl A.;Klunk, William E.;Meltzer, Carolyn C.
通讯作者：
Meltzer, Carolyn C.
影响因子：
17.7
作者：
Ballmaier, Martina;Narr, Katherine L.;Kumar, Anand
通讯作者：
Kumar, Anand
影响因子：
7.2
作者：
Ercoli, Linda M.;Siddarth, Prabha;Small, Gary W.
通讯作者：
Small, Gary W.
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B