The mediating effects of gestational diabetes on fetal growth and adiposity in women who are overweight and obese: secondary analysis of the LIMIT randomised trial.
The mediating effects of gestational diabetes on fetal growth and adiposity in women who are overweight and obese: secondary analysis of the LIMIT randomised trial.
复制标题
DOI：
10.1111/1471-0528.15288
复制
发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Dodd JM
中科院分区：
文献类型：
--
作者：
Poprzeczny AJ;Louise J;Deussen AR;Dodd JM
目的探讨妊娠期糖尿病对超重或肥胖孕妇胎儿生物测量和肥胖测量的中介作用。LIMIT随机试验的二次分析。公立医院，阿德莱德大都会，南澳大利亚。体重指数(BMI)≥25kg /m2、单胎妊娠的孕妇。使用随机分配到LIMIT试验标准护理组（n = 912名妇女）的妊娠36周胎儿超声测量值和基线BMI，使用基于回归的方法进行因果中介分析。妊娠36周胎儿生物测量和肥胖超声测量。母体BMI增加与胎儿头围（直接[无中介]效应0.18 [95% CI 0.05-0.31] p=0.005；总效应0.17 [95% CI 0.02-0.31], p=0.018）、腹围（直接效应0.26 [95% CI 0.11-0.41] p=0.001；总效应0.26 [95% CI 0.11-0.42] p=0.001）和胎儿体重(直接效应0.22 [95% CI 0.08-0.35] p=0.002；总效应0.22 [95% CI 0.08-0.35] p=0.002)，没有证据表明妊娠糖尿病治疗起到了中介作用。母亲体重指数和胎儿肥胖测量之间没有明显的联系，也没有治疗妊娠糖尿病的中介作用。我们发现母体体重指数增加与胎儿生长之间存在重要关联，而不是通过治疗妊娠糖尿病介导的。母亲体重指数增加与胎儿肥胖测量之间没有关联，也没有治疗妊娠糖尿病的中介作用。这些发现是否代表母体BMI对胎儿生长影响的“饱和”，还是GDM治疗的影响，目前尚不清楚。该项目由澳大利亚国家卫生和医学研究委员会（NHMRC）提供的为期四年的项目赠款资助（ID 519240）；南澳大利亚第七频道儿童研究基金会；美国国立卫生研究院（R01 HL094235-01）。
to describe the mediating effect of maternal gestational diabetes on fetal biometry and adiposity measures among overweight or obese pregnant women. Secondary analysis of the LIMIT randomised trial. Public hospitals, metropolitan Adelaide, South Australia. Pregnant women with body mass index (BMI) ≥ 25 kg/m2, and singleton gestation. Fetal ultrasound measures at 36 weeks’ gestation and baseline BMI from women randomised to the LIMIT trial Standard Care group (n = 912 women) were used to conduct causal mediation analyses using regression-based methods. ultrasound measures of fetal biometry and adiposity at 36 weeks’ gestation. Increased maternal BMI was associated with increased measures of fetal head circumference (direct [unmediated] effect 0.18 [95% CI 0.05–0.31] p=0.005; total effect 0.17 [95% CI 0.02–0.31], p=0.018), abdominal circumference (direct effect 0.26 [95% CI 0.11–0.41] p=0.001; total effect 0.26 [95% CI 0.11–0.42] p=0.001) and estimated fetal weight (direct effect 0.22 [95% CI 0.08–0.35] p=0.002; total effect 0.22 [95% CI 0.08–0.35] p=0.002), with no evidence of mediation by treated gestational diabetes. There was no apparent association between maternal BMI and fetal adiposity measures, nor mediation by treated gestational diabetes. We show an important association between increased maternal BMI and fetal growth, not mediated by treated gestational diabetes. There was no association between increased maternal BMI and fetal adiposity measures, nor mediation by treated gestational diabetes. Whether these findings represent “saturation” in the effect of maternal BMI on fetal growth, or the effect of treatment of GDM, is unclear. This project was funded by a four-year project grant from the National Health and Medical Research Council (NHMRC), Australia (ID 519240); The Channel 7 Children’s Research Foundation, South Australia; and the US National Institute of Health (R01 HL094235-01).
登录
查看更多内容
DOI：
10.1111/1471-0528.13777
发表时间：
2016-01
期刊：
BJOG : an international journal of obstetrics and gynaecology
影响因子：
--
作者：
Grivell RM;Yelland LN;Deussen A;Crowther CA;Dodd JM
通讯作者：
Dodd JM
影响因子：
7.2
作者：
Dashe, Jodi S.;McIntire, Donald D.;Twickler, Diane M.
通讯作者：
Twickler, Diane M.
影响因子：
6.9
作者：
Kim, Shin Y.;Dietz, Patricia M.;Callaghan, William M.
通讯作者：
Callaghan, William M.
影响因子：
19.7
作者：
HADLOCK, FP;HARRIST, RB;PARK, SK
通讯作者：
PARK, SK
DOI：
10.1016/j.ejogrb.2008.02.021
发表时间：
2008-09-01
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
Higgins, Mary F.;Russell, Noirin M.;McAuliffe, Fionnuala M.
通讯作者：
McAuliffe, Fionnuala M.