Neurological soft signs and cognitive performance in early childhood.
Neurological soft signs and cognitive performance in early childhood.
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DOI：
10.1037/dev0000566
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发表时间：
2018-11
影响因子：
4
通讯作者：
Gilman SE
中科院分区：
文献类型：
--
作者：
Alamiri B;Nelson C;Fitzmaurice GM;Murphy JM;Gilman SE
神经软征(NSS)是一种轻微的神经异常，在小规模研究中被认为是认知能力低下的危险因素。在这里，我们在一个基于人群的大型队列中调查了NSS和认知表现的多个领域之间的关联，并评估了这些关联中的性别差异。我们分析了合作围产期项目中35,710名7岁儿童的数据，使用调整了脑损伤和异常神经发育的危险因素的多元线性回归模型，研究了NSS数量和认知测试分数之间的关系。NSS与认知表现的所有领域得分较低有关。每增加一个软体征与较低的总分智商(b=−4.83，95%CI=−5.06，−4.60)、操作智商(b=−4.28，CI=−4.54，−4.02)和言语智商得分(b=−4.53，CI=−4.76，−4.30)相关；以及算术(b=−4.06，CI=−4.26，−3.85)、拼写(b=−3.53，CI=−3.75，−3.30)和阅读(b=−4.00，CI=−4.26，−3.75)。只有一个性别差异：女生(b=−4.01，CI=−4.26，−3.36)与WRAT拼写测试的关联性比男生(b=−3.53，CI=−3.75，−3.30)更强。NSS与认知能力低下之间存在关联，这与脑损伤和异常神经发育的既定风险因素无关。需要进一步的研究来调查这种联系的潜在机制，并确定针对儿童NSS的干预措施是否对神经认知发育有有益影响。
Neurological Soft Signs (NSS), minor neurological abnormalities, have been implicated as risk factors for poor cognitive performance in small-scale studies. Here we investigate the associations between NSS and multiple domains of cognitive performance in a large, population-based cohort and evaluate sex differences in these associations. We analyzed data from 35,710 seven-year old children in the Collaborative Perinatal Project to study the association between the number of NSS and cognitive test scores using multiple linear regression models adjusting for risk factors for brain injury and aberrant neurodevelopment. NSS were associated with lower scores on all domains of cognitive performance. Each additional soft sign was associated with lower full scale IQ (b =−4.83, 95% CI = −5.06, −4.60), performance IQ (b = −4.28, CI = −4.54, −4.02), and verbal IQ scores (b = −4.53, CI = −4.76, −4.30); as well as arithmetic (b = −4.06, CI = −4.26, −3.85), spelling (b = −3.53, CI = −3.75, −3.30), and reading (b = −4.00, CI = −4.26,−3.75) scores on the Wide Range Achievement Test (WRAT). Only one sex difference was observed: the association between NSS and the WRAT spelling test was somewhat stronger in girls (b= −4.01, CI = −4.26, −3.36) than in boys (b= −3.53, CI= −3.75, −3.30). There is an association between NSS and poor cognitive performance that is not attributable to established risk factors for brain injury and aberrant neurodevelopment. Further research is needed to investigate the mechanisms underlying this association and to determine if interventions targeting NSS in children might have beneficial effects on neurocognitive development.
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影响因子：
11.3
作者：
CHEN, EYH;SHAPLESKE, J;BERRIOS, GE
通讯作者：
BERRIOS, GE
影响因子：
10.6
作者：
Breslau, N;Chilcoat, HD;Lucia, VC
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影响因子：
3.7
作者：
Dazzan, Paola;Morgan, Kevin D.;Murray, Robin M.
通讯作者：
Murray, Robin M.
影响因子：
5.6
作者：
Hardy, JB
通讯作者：
Hardy, JB
影响因子：
10.5
作者：
Dazzan, P;Murray, RM
通讯作者：
Murray, RM