Altered error-related brain activity in youth with major depression.
Altered error-related brain activity in youth with major depression.
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DOI：
10.1016/j.dcn.2012.01.005
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发表时间：
2012-07
影响因子：
4.7
通讯作者：
Ryan, Neal D.
中科院分区：
文献类型：
--
作者：
Ladouceur, Cecile D.;Slifka, John S.;Dahl, Ronald E.;Birmaher, Boris;Axelson, David A.;Ryan, Neal D.
抑郁症与认知控制障碍有关，包括动作监测过程，其涉及检测和处理错误反应以调整行为。尽管许多研究都报告了抑郁症成年人与错误相关的大脑活动发生了变化，但人们对抑郁症青少年与错误相关的大脑活动中与年龄相关的变化知之甚少。本研究的重点是错误相关负波（ERN），事件相关电位（ERP）的负向偏转，最大约50 ms的错误。在24名诊断为MDD的青年和14名低风险健康对照（HC）中，对侧翼任务的反应进行了高密度ERPs检查。结果表明，与HC相比，MDD青年的ERN振幅显着较小，并没有表现出正常的增加ERN振幅作为年龄的函数。此外，ERN振幅在有和没有共病焦虑的抑郁青年中相似。这些结果表明，抑郁的青年表现出不同的年龄相关的大脑活动与行动监测过程的变化。调查结果进行了讨论，在现有的工作神经相关的行动监测和抑郁症和需要纵向研究调查的发展神经系统的基础上的行动监测诊断为抑郁症的青年和风险。
Depression is associated with impairments in cognitive control including action monitoring processes, which involve the detection and processing of erroneous responses in order to adjust behavior. Although numerous studies have reported altered error-related brain activity in depressed adults, relatively little is known about age-related changes in error-related brain activity in depressed youth. This study focuses on the error-related negativity (ERN), a negative deflection in the event-related potential (ERP) that is maximal approximately 50 ms following errors. High-density ERPs were examined following responses on a flanker task in 24 youth diagnosed with MDD and 14 low-risk healthy controls (HC). Results indicate that compared to HC, MDD youth had significantly smaller ERN amplitudes and did not exhibit the normative increases in ERN amplitudes as a function of age. Also, ERN amplitudes were similar in depressed youth with and without comorbid anxiety. These results suggest that depressed youth exhibit different age-related changes in brain activity associated with action monitoring processes. Findings are discussed in terms of existing work on the neural correlates of action monitoring and depression and the need for longitudinal research studies investigating the development of neural systems underlying action monitoring in youth diagnosed with and at risk for depression.
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影响因子：
2.5
作者：
Cunningham, MG;Bhattacharyya, S;Benes, FM
通讯作者：
Benes, FM
DOI：
10.1080/09297040802577311
发表时间：
2009-01
期刊：
Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
影响因子：
--
作者：
Favre T;Hughes C;Emslie G;Stavinoha P;Kennard B;Carmody T
通讯作者：
Carmody T
DOI：
10.1097/00004583-199704000-00018
发表时间：
1997-04-01
影响因子：
13.3
作者：
Birmaher, B;Khetarpal, S;Neer, SM
通讯作者：
Neer, SM
影响因子：
6.9
作者：
Beats, BC;Sahakian, BJ;Levy, R
通讯作者：
Levy, R
影响因子：
6.9
作者：
Elliott, R;Sahakian, BJ;Dolan, RJ
通讯作者：
Dolan, RJ