Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampus.
Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampus.
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DOI：
10.1289/ehp.9645
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发表时间：
2007-04
影响因子：
10.4
通讯作者：
Wright RO
中科院分区：
文献类型：
--
作者：
Weisskopf MG;Hu H;Sparrow D;Lenkinski RE;Wright RO
已知铅暴露对几个不同人群的认知有不利影响。对于人类暴露于这种物质的潜在结构和功能相关性，我们所知甚少。我们使用磁共振波谱（MRS）评估了体内铅累积暴露与不同脑代谢物比率水平之间的关系。我们从退伍军人事务部的规范衰老研究（NAS）中选择髌骨铅最低五分之一的15名男性和从最高五分之一的16名男性进行了磁共振成像，以评估海马代谢物n -乙酰天冬氨酸、肌醇和胆碱的水平，每一种都以肌酸的比例表达。骨铅浓度-累积铅暴露的指标-以前使用k - x射线荧光光谱测量。从2002年到2004年，对这些男性进行了MRS手术。20 μg/g骨和15 μg骨的髌骨和胫骨骨铅浓度较高（在整个nas中各自的四分位数范围内），相关系数为0.04[95%置信区间（CI）， 0.00-0.08；p = 0.04]和0.04 （95% CI, 0.00-0.08; p = 0.07）海马肌醇与肌酸比值升高。在考虑了髌骨骨铅随时间的下降后，根据年龄调整的分析显示，20 μg/g骨高的髌骨骨铅水平的影响翻了一番（0.09;95% CI, 0.01-0.17; p = 0.03）。累积铅暴露与肌醇与肌酸比值的增加有关。这些数据表明，通过核磁共振评估，作为成人铅累积暴露的指标，神经胶质效应可能比神经元效应更敏感。
Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans. We assessed the association between cumulative exposure to lead and levels of different brain metabolite ratios in vivo using magnetic resonance spectroscopy (MRS). We performed MRS on 15 men selected from the lowest quintile of patella bone lead within the Department of Veterans Affairs’ Normative Aging Study (NAS) and 16 from the highest to assess in the hippocampal levels of the metabolites N-acetylaspartate, myoinositol, and choline, each expressed as a ratio with creatine. Bone lead concentrations—indicators of cumulative lead exposure—were previously measured using K-X-ray fluorescence spectroscopy. MRS was performed on the men from 2002 to 2004. A 20-μg/g bone and 15-μg/g bone higher patella and tibia bone lead concentration—the respective interquartile ranges within the whole NAS—were associated with a 0.04 [95% confidence interval (CI), 0.00–0.08; p = 0.04] and 0.04 (95% CI, 0.00–0.08; p = 0.07) higher myoinositol-to-creatine ratio in the hippocampus. After accounting for patella bone lead declines over time, analyses adjusted for age showed that the effect of a 20-μg/g bone higher patella bone lead level doubled (0.09; 95% CI, 0.01–0.17; p = 0.03). Cumulative lead exposure is associated with an increase in the myinositol-to-creatine ratio. These data suggest that, as assessed with MRS, glial effects may be more sensitive than neuronal effects as an indicator of cumulative exposure to lead in adults.
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影响因子：
3.3
作者：
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通讯作者：
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作者：
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作者：
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通讯作者：
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