Partial normalization of components of metabolic syndrome does not influence prevalent echocardiographic abnormalities: the HyperGEN study.
Partial normalization of components of metabolic syndrome does not influence prevalent echocardiographic abnormalities: the HyperGEN study.
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DOI：
10.1016/j.numecd.2011.02.004
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Devereux RB
中科院分区：
文献类型：
--
作者：
de Simone G;Arnett DK;Chinali M;De Marco M;Rao DC;Kraja AT;Hunt SC;Devereux RB
代谢综合征（MetS）是一种复杂的疾病，其特征在于不同的表型，根据风险因素的组合，并与心血管异常相关。通过治疗控制MetS组分是否能改善相关的心血管异常尚不清楚。我们研究了是否部分控制代谢综合征的组成部分与较少的超声心动图异常比完全介绍代谢综合征的基础上测量的组成部分。我们在1，421名非裔美国人和1，195名白人非糖尿病HyperGEN参与者中评估了MetS（ATP III）中超声心动图临床前心血管疾病的标志物，这些标志物由测量的成分或治疗史定义，没有流行的心血管疾病或血清肌酐>2 mg/dL。在2，616名受试者中，512名受试者根据测量的成分和328名受试者根据病史患有MetS。高血压被发现在16%的参与者没有代谢综合征，6%的代谢综合征的历史和42%的代谢综合征的测量组件。两个MetS组的肥胖和中央脂肪分布患病率相似（均p<0.0001 vs No-MetS）。代谢综合征患者的血压与非代谢综合征患者的血压相似，但低于代谢综合征患者的血压（p<0.0001）。两个MetS组的LV质量和中壁缩短、左心房（LA）尺寸和LA收缩力均异常（均p<0.0001，与无MetS组相比），两组之间无差异。通过治疗MetS的单一组分（即高血压）控制对超声心动图异常的影响很小。MetS患者的血压降低与心脏几何结构和功能改变的显著减少无关。
Metabolic syndrome (MetS) is a complex condition characterized by different phenotypes, according to combinations of risk factors and is associated with cardiovascular abnormalities. Whether control of MetS components by treatment produces improvement in the associated cardiovascular abnormalities is unknown. We investigated whether partial control of components of MetS was associated with less echocardiographic abnormalities than the complete presentation of MetS based on measured components. We evaluated markers of echocardiographic preclinical cardiovascular disease in MetS (ATPIII) defined by measured components or by history of treatment, in 1,421 African- American and 1,195 Caucasian non-diabetic HyperGEN participants, without prevalent cardiovascular disease or serum creatinine>2 mg/dL. Of 2,616 subjects, 512 subjects had MetS by measured components and 328 by history. Hypertension was found in 16% of participants without MetS, 6% of those with MetS by history and 42% of those with MetS by measured components. Obesity and central fat distribution had similar prevalence in both MetS groups (both p<0.0001 vs No-MetS). Blood pressure was similar in MetS by history and No-MetS, and lower than in MetS by measured components (p<0.0001). LV mass and midwall shortening, left atrial (LA) dimension and LA systolic force were similarly abnormal in both MetS groups (all p<0.0001 vs. No-MetS) without difference between them. There is little impact of control by treatment of single components of MetS (namely hypertension) on echocardiographic abnormalities. Lower blood pressure in participants with MetS by history was not associated with substantially reduced alterations in cardiac geometry and function.
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影响因子：
37.8
作者：
Devereux, RB;Roman, MJ;Howard, BV
通讯作者：
Howard, BV
影响因子：
168.9
作者：
Bray, G. A.;Chatellier, A.;Duncan, C.;Greenway, F. L.;Levy, E.;Ryan, D. H.;Polonsky, K. S.;Tobian, J.;Ehrmann, D.;Matulik, M. J.;Clark, B.;Czech, K.;DeSandre, C.;Hilbrich, R.;McNabb, W.;Semenske, A. R.;Goldstein, B. J.;Smith, K. A.;Wildman, W.;Pepe, C.;Goldberg, R. B.;Calles, J.;Ojito, J.;Castillo-Florez, S.;Florez, H. J.;Giannella, A.;Lara, O.;Veciana, B.;Haffner, S. M.;Montez, M. G.;Lorenzo, C.;Martinez, A.;Hamman, R. F.;Testaverde, L.;Bouffard, A.;Dabelea, D.;Jenkins, T.;Lenz, D.;Perreault, L.;Price, D. W.;Steinke, S. C.;Horton, E. S.;Poirier, C. S.;Swift, K.;Caballero, E.;Jackson, S. D.;Lambert, L.;Lawton, K. E.;Ledbury, S.;Kahn, S. E.;Montgomery, B. K.;Fujimoto, W.;Knopp, R. H.;Lipkin, E. W.;Marr, M.;Murillo, A.;Trence, D.;Kitabchi, A. E.;Murphy, M. E.;Applegate, W. B.;Bryer-Ash, M.;Dagogo-Jack, S.;Frieson, S. L.;Lambeth, H.;Lichtermann, L. C.;Otkaei, H.;Rutledge, L. M. K.;Sherman, A. R.;Smith, C. M.;Soberman, J. E.;Williams-Cleaves, B.;Metzger, B. E.;Molitch, M. E.;Johnson, M. K.;Giles, M. M.;Larsen, D.;Niznik, C.;Pen, S. C.;Schinleber, P. A.;Nathan, D. M.;McKitrick, C.;Turgeon, H.;Abbott, K.;Altshuler, D.;Anderson, E.;Bissett, L.;Cagliero, E.;D'Anna, K.;Delahanty, L.;Florez, J. C.;Goldman, V.;Poulos, A.;Tseng, B.;Barrett-Connor, E.;Carrion-Petersen, M. L.;Horne, J.;Leos, D.;Mudaliar, S.;Smith, J.;Vejvoda, K.;Pi-Sunyer, F. X.;Lee, J. E.;Foo, S. T.;Hagamen, S.;Marrero, D. G.;Kelly, S. M.;Ackermann, R. T.;Fineberg, E. S.;Hadden, A.;Jackson, M. A.;Kirkman, M. S.;Mather, K. J.;Roach, P. J.;Wheeler, M. L.;Ratner, R. E.;Aroda, V.;Shapiro, S.;Bavido-Arrage, C.;Gibbs, P.;Uwaifo, Gl;Wiggins, R.;Saad, M. F.;Watson, K.;Botrous, M.;Jinagouda, S.;Budget, M.;Conzues, C.;Magpuri, P.;Ngo, K.;Xapthalamous, K.;White, N. H.;Das, S.;Santiago, A.;Brown, A. L.;Wernimont, C.;Saudek, C. D.;Whittington, T.;Clark, J. M.;Greene, A.;Jiggetts, D.;Mosley, H.;Reusing, J.;Rubin, R. R.;Stephen, S.;Utsey, E.;Schade, D. S.;Adams, K. S.;Hemphill, C.;Hyde, P.;Butler, L.;Canady, J. L.;Colleran, K.;Gonzales, Y.;Hernandez-McGinnis, D. A.;Katz, P.;King, C.;Crandall, J.;Brown-Friday, J. O.;Adorno, E.;Duffy, H.;Martinez, H.;Pompi, D.;Shamoon, H.;Walker, E. A.;Wylie-Rosett, J.;Orchard, T.;Jeffries, S.;Kramer, M. K.;Smith, M.;Kriska, A.;Pettigrew, J.;Semler, L.;Venditti, E.;Weinzierl, V.;Arakaki, R. F.;Baker-Ladao, N. K.;Isonaga, M. K.;Bermudez, N. E.;Mau, M. K.;Knowler, W. C.;Cooeyate, N.;Hoskin, M. A.;Natewa, C.;Percy, C. A.;Acton, K. J.;Andre, V. L.;Begay, S.;Bucca, B. C.;Cook, S.;Doughty, M. S.;Glass, J.;Glass, M.;Hanson, R. L.;Hassenpflug, D.;Ingraham, L. E.;Kobus, K. M.;Krakoff, J.;Manus, C.;McCabe, C.;Michaels, S.;Morgan, T.;Nelson, J. A.;Roy, R. J.;Smart, M.;Tonemah, D. P.;Wilson, C.;Fowler, S.;Brenneman, T.;Abebe, S.;Bamdad, J.;Callaghan, J.;Christophi, C. A.;Edelstein, S. L.;Gao, Y.;Gooding, R.;Gottlieb, A.;Grover, N.;Hoffman, H.;Jablonski, K.;Katz, R.;Kolinjivadi, P.;Lachin, J. M.;Ma, Y.;Reamer, S.;Sapozhnikova, A.;Sherif, H.;Temprosa, M.;Venditti, E. M.;Kriska, A. M.;Semler, L.;Weinzierl, V.;Marcovina, S.;Strylewicz, G.;Albers, J.;Prineas, R. J.;Alexander, T.;Campbell, C.;Hall, S.;Hensley, S.;Li, Y.;Mills, M.;Soliman, E.;Zhang, Z.;Fradkin, J.;Garfield, S.;Mayer-Davis, E.;Moran, R. R.;Ganiats, T.;Sarkin, A. J.
通讯作者：
Sarkin, A. J.
DOI：
10.1016/0735-1097(94)90390-5
发表时间：
1994-05-01
影响因子：
24
作者：
DESIMONE, G;DEVEREUX, RB;LARAGH, JH
通讯作者：
LARAGH, JH
影响因子：
2.8
作者：
Chinali, M;Devereux, RB;de Simone, G
通讯作者：
de Simone, G
影响因子：
3.2
作者：
Cuspidi, Cesare;Meani, Stefano;Mancia, Giuseppe
通讯作者：
Mancia, Giuseppe