Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling.
Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling.
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中药治疗心室重构的细胞分子机制
DOI：
10.3389/fcvm.2021.753095
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发表时间：
2021
影响因子：
3.6
通讯作者：
Gu N
中科院分区：
文献类型：
--
作者：
Zhu YC;Liang B;Gu N
心室重构与肾素-血管紧张素-醛固酮系统、免疫系统以及参与炎症、凋亡和细胞信号调节的各种细胞因子有关。大量研究表明，中药能显著抑制心室重构的进程，其机制可能与上述机制有关。本文就中药抗心室重构的细胞分子机制作一系统综述。主要检索PubMed近5年来有关中药抗心室重构的基础研究，并对这些研究进行客观的总结。我们纳入了包括芪李潜心、芪参益气丸、心肌二康方、益气温阳汤等25种以上的中草药，发现它们通过多成分、多作用靶点有效抑制心室重构，正在推动中医药的临床应用。
Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular remodeling, which may be related to the mechanism mentioned above. Here, we conducted a system overview to critically review the cellular and molecular mechanism of traditional Chinese medicine on ventricular remodeling. We mainly searched PubMed for basic research about the anti-ventricular remodeling of traditional Chinese medicine in 5 recent years, and then objectively summarized these researches. We included more than 25 kinds of Chinese herbal medicines including Qi-Li-Qian-Xin, Qi-Shen-Yi-Qi Pill, Xin-Ji-Er-Kang Formula, and Yi-Qi-Wen-Yang Decoction, and found that they can inhibit ventricular remodeling effectively through multi-components and multi-action targets, which are promoting the clinical application of traditional Chinese medicine.
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DOI：
10.1155/2020/3439191
发表时间：
2020
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Deng LH;Li L;Zhai Y;Michael S;Yang CY;Guo R;Chen SF;Fan GW;Zhao YQ;Liu W
通讯作者：
Liu W
影响因子：
18.2
作者：
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通讯作者：
Díez J
DOI：
10.1155/2017/3217395
发表时间：
2017
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Cen W;Chen Z;Gu N;Hoppe R
通讯作者：
Hoppe R
影响因子：
10.8
作者：
Chou, Chia-Hung;Hung, Chi-Sheng;Lin, Yen-Hung
通讯作者：
Lin, Yen-Hung
DOI：
10.1155/2016/4682786
发表时间：
2016
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Chai CZ;Mo WL;Zhuang XF;Kou JP;Yan YQ;Yu BY
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Yu BY