Impact of Cancer Cachexia on Hospitalization-associated Physical Inactivity in Elderly Patients with Advanced Non-small-cell Lung Cancer.
Impact of Cancer Cachexia on Hospitalization-associated Physical Inactivity in Elderly Patients with Advanced Non-small-cell Lung Cancer.
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DOI：
10.4103/apjon.apjon_20_18
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发表时间：
2018-10
影响因子：
1.8
通讯作者：
Takahashi T
中科院分区：
文献类型：
--
作者：
Morikawa A;Naito T;Sugiyama M;Okayama T;Aoyama T;Tanuma A;Omae K;Takahashi T
新的或恶化的残疾可能在老年患者中发生，在急性疾病住院治疗的短短一周内。老年癌症患者，特别是癌症恶病质患者，很容易残疾。本研究旨在探讨住院和恶病质对老年患者化疗期间体力活动的影响。我们前瞻性入组了18例年龄≥70岁的新诊断晚期非小细胞肺癌患者，计划开始一线化疗。使用加速度计（Lifecorder®，Suzuken Co.，有限公司、日本）。比较基线、住院期间和随后几周（出院后第1、2和3周）的平均每日步数。共对18例患者的30次住院化疗进行了评价，中位年龄为74.5岁。基线每日步数的中位数为3756。15例（50%）患者在住院期间出现每日步数减少，出院后第1周未恢复至基线水平。长期住院（≥8天）和恶病质的存在与持续的身体活动不足有关。1例患者在住院后30天内发生残疾。老年晚期肺癌患者住院化疗后经常缺乏体力活动。较长的住院天数和癌症恶病质的存在导致身体活动恢复缓慢。可能需要基于仔细考虑患者年龄和癌症恶病质的存在的个体化住院计划，以防止身体活动不足和残疾。
New or worsening disability can develop in elderly patients in just 1 week of hospitalization for acute illness. Elderly patients with cancer, particularly those with cancer cachexia, are vulnerable to disability. This study aimed to explore the impact of hospitalization and cachexia on physical activity (PA) in elderly patients during chemotherapy. We prospectively enrolled 18 patients aged ≥70 years with newly-diagnosed, advanced non-small-cell lung cancer scheduled to initiate first-line chemotherapy. PA was measured using an accelerometer (Lifecorder®, Suzuken Co., Ltd., Japan). Mean daily steps at baseline, during hospitalization, and subsequent weeks (1st, 2nd, and 3rd week after discharge) were compared. A total of 30 hospitalizations for chemotherapy were evaluated in 18 patients with a median age of 74.5 years. The median number of baseline daily steps was 3756. Fifteen cases (50%) showed fewer daily steps during hospitalization and no recovery to baseline level during the 1st week after discharge. Long hospitalizations (≥8 days) and the presence of cachexia were associated with persistent physical inactivity. One patient developed disability within 30 days after hospitalization. Physical inactivity was frequently seen after hospitalization for chemotherapy in elderly patients with advanced lung cancer. Longer in-hospital days and the presence of cancer cachexia caused slow recovery from physical inactivity. Individualized hospitalization planning based on careful consideration of patient age and the presence of cancer cachexia may be needed to prevent physical inactivity and disability.
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影响因子：
3.8
作者：
Naito T;Okayama T;Aoyama T;Ohashi T;Masuda Y;Kimura M;Shiozaki H;Murakami H;Kenmotsu H;Taira T;Ono A;Wakuda K;Imai H;Oyakawa T;Ishii T;Omori S;Nakashima K;Endo M;Omae K;Mori K;Yamamoto N;Tanuma A;Takahashi T
通讯作者：
Takahashi T
影响因子：
120.7
作者：
Covinsky, Kenneth E.;Pierluissi, Edgar;Johnston, C. Bree
通讯作者：
Johnston, C. Bree
影响因子：
1.5
作者：
Yasunaga, Akitomo;Togo, Fumiharu;Aoyagi, Yukitoshi
通讯作者：
Aoyagi, Yukitoshi
影响因子：
5.7
作者：
Kelley, Amy S.;Ettner, Susan L.;Sarkisian, Catherine A.
通讯作者：
Sarkisian, Catherine A.
DOI：
10.1016/j.jamda.2015.03.011
发表时间：
2015-08-01
影响因子：
7.6
作者：
Sourdet, Sandrine;Lafont, Christine;Vellas, Bruno
通讯作者：
Vellas, Bruno