Early adversity changes the economic conditions of structural brain network organisation
Early adversity changes the economic conditions of structural brain network organisation
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早期逆境改变了结构性脑网络组织的经济条件
DOI：
10.1101/2022.06.08.495303
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
D. Astle
中科院分区：
文献类型：
--
作者：
Sofia Carozza;Joni Holmes;P. Vértes;E. Bullmore;Tanzil Mahmud Arefin;Alexa Pugliese;Jiangyang Zhang;Arie Kaffman;Danyal Akarca;D. Astle
早期的逆境可以改变教育、认知和心理健康结果。然而，早期逆境发挥这些影响的神经过程仍然很大程度上未知。我们使用小鼠连接组的生成网络模型来测试不可预测的产后应激是否会改变控制结构连接组形成的约束。一个模型用拓扑同质性（即具有共享邻居的区域之间的链接）来权衡长距离连接的布线成本，生成了复制啮齿动物连接组组织的模拟。早年遭遇的逆境显着地将表现最好的参数组合转向零，从而增强了生成过程的随机性。简而言之，不可预测的产后压力改变了塑造网络形成的经济约束，为大脑的结构发育带来了更大的随机性。虽然这种变化可能会限制认知能力的发展，但它也可能反映了一种适应机制。换句话说，神经发育可以利用增强的随机性使网络对扰动更加鲁棒，从而促进对未来威胁和挑战的有效响应。意义陈述 早年经历逆境（例如长期贫困或虐待）的儿童表现出许多神经差异，这些差异与日后认知能力和心理健康状况较差有关。为了有效减轻逆境负担，确定这些差异是如何产生的至关重要。在本文中，我们使用计算模型来测试在贫困和不可预测的环境中成长是否会改变小鼠大脑结构连接的发展。我们发现早期的逆境似乎在神经结构的形成中引入了更多的随机性。我们的研究结果指出了早期逆境如何改变儿童发展进程的潜在机制。
Early adversity can change educational, cognitive, and mental health outcomes. However, the neural processes through which early adversity exerts these effects remain largely unknown. We used generative network modelling of the mouse connectome to test whether unpredictable postnatal stress shifts the constraints that govern the formation of the structural connectome. A model that trades off the wiring cost of long-distance connections with topological homophily (i.e. links between regions with shared neighbours) generated simulations that replicate the organisation of the rodent connectome. The imposition of early life adversity significantly shifted the best-performing parameter combinations toward zero, heightening the stochastic nature of the generative process. Put simply, unpredictable postnatal stress changes the economic constraints that shape network formation, introducing greater randomness into the structural development of the brain. While this change may constrain the development of cognitive abilities, it could also reflect an adaptive mechanism. In other words, neural development could harness heightened stochasticity to make networks more robust to perturbation, thereby facilitating effective responses to future threats and challenges. Significance statement Children who experience adversity early in life – such as chronic poverty or abuse – show numerous neural differences that are linked to poorer cognition and mental health later in life. To effectively mitigate the burden of adversity, it is critical to identify how these differences arise. In this paper, we use computational modelling to test whether growing up in an impoverished and unpredictable environment changes the development of structural connections in the mouse brain. We found that early adversity appears to introduce more stochasticity in the formation of neural architecture. Our findings point to a potential mechanism for how early adversity could change the course of child development.
影响因子：
4.6
作者：
Beul SF;Barbas H;Hilgetag CC
通讯作者：
Hilgetag CC
DOI：
10.1073/pnas.0506806103
发表时间：
2006-03-21
影响因子：
11.1
作者：
Chen, BL;Hall, DH;Chklovskii, DB
通讯作者：
Chklovskii, DB