Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery.
Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery.
复制标题
功能连通性的地形测量作为中风后运动恢复的生物标志物。
DOI：
10.1186/s12984-017-0277-3
复制
发表时间：
2017-07-06
影响因子：
5.1
通讯作者：
Príncipe JC
中科院分区：
文献类型：
--
作者：
Philips GR;Daly JJ;Príncipe JC
来自大脑神经活动的生物标记物为中风后运动恢复的预测和评估以及实时生物反馈机会提供了重要的工具。为了将与恢复相关的脑网络重组概括为这样的生物标志物，我们利用了广义关联度(GMA)和图形分析，包括全局和局部效率，以及半球内密度和内部密度。这些方法被应用于一项对30名中风幸存者(21名男性，平均年龄57.9岁，平均中风持续时间22.4个月)进行12周强化治疗干预的研究中记录的脑电数据。我们观察到，健侧大脑半球内部密度的降低与功能恢复相关(r S=FMUE0.46；P<；0.05)，这与−-Meyer上肢部分的功能恢复有关。此外，局部效率的高初始值预示着FMUE有更大的改善(R2=0.16；p<；0.05)。在17名大脑皮质受损的受试者中，发现整体和局部效率的降低以及健侧大脑半球的内部密度与功能改善有关(r S=−0.60，−0.66，−0.75；p<；0.05)。在同一亚组内，整体和局部效率的高初始值预示着恢复的改善(R2=0.24，0.25；p<；0.05)。所有有意义的发现都是针对12.5-25赫兹频段的。这些拓扑测量显示了预后和治疗结果评估的前景，以及潜在的应用于脑机接口使能的生物反馈。
Biomarkers derived from neural activity of the brain present a vital tool for the prediction and evaluation of post-stroke motor recovery, as well as for real-time biofeedback opportunities. In order to encapsulate recovery-related reorganization of brain networks into such biomarkers, we have utilized the generalized measure of association (GMA) and graph analyses, which include global and local efficiency, as well as hemispheric interdensity and intradensity. These methods were applied to electroencephalogram (EEG) data recorded during a study of 30 stroke survivors (21 male, mean age 57.9 years, mean stroke duration 22.4 months) undergoing 12 weeks of intensive therapeutic intervention. We observed that decreases of the intradensity of the unaffected hemisphere are correlated (r s=−0.46;p<0.05) with functional recovery, as measured by the upper-extremity portion of the Fugl-Meyer Assessment (FMUE). In addition, high initial values of local efficiency predict greater improvement in FMUE (R 2=0.16;p<0.05). In a subset of 17 subjects possessing lesions of the cerebral cortex, reductions of global and local efficiency, as well as the intradensity of the unaffected hemisphere are found to be associated with functional improvement (r s=−0.60,−0.66,−0.75;p<0.05). Within the same subgroup, high initial values of global and local efficiency, are predictive of improved recovery (R 2=0.24,0.25;p<0.05). All significant findings were specific to the 12.5–25 Hz band. These topological measures show promise for prognosis and evaluation of therapeutic outcomes, as well as potential application to BCI-enabled biofeedback.
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
3
作者：
Bastos AM;Schoffelen JM
通讯作者：
Schoffelen JM
影响因子：
8.3
作者：
Cramer, SC;Nelles, G;Rosen, BR
通讯作者：
Rosen, BR
影响因子：
2
作者：
Ang, Kai Keng;Chua, Karen Sui Geok;Guan, Cuntai
通讯作者：
Guan, Cuntai
影响因子：
--
作者：
Dancause, Numa;Nudo, Randolph J.
通讯作者：
Nudo, Randolph J.