The cardiovascular response of normal rats to dual lesion of the subfornical organ and area postrema at rest and to chronic losartan.
The cardiovascular response of normal rats to dual lesion of the subfornical organ and area postrema at rest and to chronic losartan.
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DOI：
10.1016/j.brainres.2009.09.021
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发表时间：
2009-12-11
期刊：
影响因子：
2.9
通讯作者：
Nahey, David B.
中科院分区：
文献类型：
--
作者：
Collister, John P.;Nahey, David B.
穹隆下器(SFO)和最后区(AP)是脑室周围感觉器官(CVO)中的两个器官，在慢性中枢控制血压中起着重要作用。在以前的研究中，这些区域是独立受损的，AT1受体阻滞剂氯沙坦(10 mg/kg/天)的慢性降压作用被减弱约15毫米汞柱。在本研究中，我们试图研究同时损毁SFO和AP对慢性注射氯沙坦的心血管效应的影响，以验证这样一种假设，即在双重损毁的大鼠中，可以观察到更大程度地减弱氯沙坦的降压作用。为此，我们比较了假手术组和AP和SFO双重损毁组大鼠10天注射氯沙坦后的动脉压和心率反应。这项研究得出了两个重要的发现。首先，与假手术组相比，双侧损毁组大鼠的静息血压(分别为83±1 mm Hg和104±1 mm Hg)和心率(分别为356±3 bpm和398±6 bpm)持续显著降低。其次，与假手术组相比，同时损毁AP和SFO的大鼠对氯沙坦的反应显著减弱，但对氯沙坦的慢性降压作用的减弱程度并不比损毁SFO或AP的大鼠更大(~15 mm Hg)。尽管这些结果不支持上述假设，但它们确实表明AP和SFO在基础心血管控制中的冗余和代偿作用。
The subfornical organ (SFO) and the area postrema (AP), two of the sensory circumventricular organs (CVO), are known to play a role in the chronic central control of blood pressure. In previous studies in which these regions were independently lesioned, the chronic hypotensive effects of the AT1 receptor blocker losartan (10mg/kg/day) were attenuated by ~15mmHg. In the present study, we sought to investigate the effect of concurrent lesion of both the SFO and the AP on the cardiovascular effects of chronic losartan infusion in order to test the hypothesis that a greater attenuation of the hypotensive effects of losartan would be observed in rats with dual lesions. To do so, arterial pressure and heart rate responses to 10 day infusion of losartan were compared in sham rats and those with dual lesions of the AP and SFO. Two important findings resulted from this study. First, dual lesion rats exhibited a sustained and significant decrease in resting blood pressure (83±1 mmHg vs. 104±1 mmHg, respectively) and heart rate (356±3 bpm vs. 398±6 bpm, respectively) compared to sham animals. Secondly, rats with concurrent lesion of both the AP and the SFO demonstrated a significantly attenuated response to losartan compared to sham animals but showed no greater attenuation of losartan’s chronic hypotensive effects than animals with lesion of either the SFO or the AP (~15mmHg). Although these results do not support the stated hypothesis, they do suggest redundancy and compensatory roles of the AP and SFO in basal cardiovascular control.
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影响因子：
8.3
作者：
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