Five-year follow-up optic disc findings of the Collaborative Initial Glaucoma Treatment Study.
Five-year follow-up optic disc findings of the Collaborative Initial Glaucoma Treatment Study.
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DOI：
10.1016/j.ajo.2008.10.007
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发表时间：
2009-04
影响因子：
4.2
通讯作者：
Musch, David C.
中科院分区：
文献类型：
--
作者：
Parrish, Richard K., II;Feuer, William J.;Schiffman, Joyce C.;Lichter, Paul R.;Musch, David C.
确定青光眼初始治疗协作研究（CIGTS）患者5年后降低眼内压（IOP）对视盘的影响。随机临床试验由两名独立的阅片员对随机接受开角型青光眼药物或手术治疗的348只眼睛（患者）的基线和5年立体视盘照片进行了评估，以进行盲法并排比较，并由独立委员会确认。303只（87.1%）眼无变化，22只（6.3%）眼显示沿任何子午线的髋臼杯沿着增大（进展），23只（6.6%）显示沿任何子午线的髋臼杯沿着减小（倒杯）。药物组的视盘进展发生率（18/185（10%））高于手术组（4/163（3%），P= 0.007）;手术组的拔罐逆转发生率（21/163（13%））高于药物组（2/185（1%），P<0.001）。视野恶化（平均偏差）与视盘杯状病变的进展显著相关（P<0.001）。拔火罐后眼压明显降低（P<0.001）。恢复拔火罐与视力或中心视野的改善无关。手术可预防或延迟早期开角型青光眼患者的视神经盘标准测量的青光眼进展。拔火罐复发率手术组高于药物治疗组。视网膜病变与较低的IOP相关，但与视觉功能改善无关。
To determine the effect of intraocular pressure (IOP) lowering on the optic disc in patients of the Collaborative Initial Glaucoma Treatment Study (CIGTS) after five years. Randomized clinical trial The baseline and five-year stereoscopic optic disc photographs of 348 eyes (patients) randomized to medical or surgical treatment of open-angle glaucoma were assessed by two independent readers for change in a masked side-by-side comparison, and confirmed by an independent committee. 303 (87.1%) eyes showed no change, 22 (6.3%) showed enlargement of the cup along any meridian (progression), and 23 (6.6%) showed a reduction in the cup along any meridian (reversal of cupping). Incidence of optic disc progression was higher (p=0.007) in the medicine group, 18/185 (10%) than in the surgical group 4/163 (3%); and the incidence of reversal of cupping was higher (p<0.001) in the surgical group, 21/163 (13%), than the medicine group, 2/185 (1%), (P<0.001). Visual field worsening (mean deviation) was significantly associated with progression of optic disc cupping (P<0.001). Reversal of cupping was also associated with lower postoperative IOP (P<0.001). Reversal of cupping was not associated with improvement of either visual acuity or central visual fields. Surgery prevents or delays glaucomatous progression as measured by optic disc criteria in patients with early open-angle glaucoma. Reversal of cupping occurs more frequently in the surgical group than in the medical treatment group. Reversal is associated with lower IOP, but is not associated with improved visual function.
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影响因子：
4.2
作者：
HENKIND, P;CHARLES, NC;PEARSON, J
通讯作者：
PEARSON, J
影响因子：
4.2
作者：
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影响因子：
13.7
作者：
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通讯作者：
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影响因子：
13.7
作者：
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通讯作者：
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影响因子：
13.7
作者：
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通讯作者：
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