Air pollution and ST-segment depression in elderly subjects.
Air pollution and ST-segment depression in elderly subjects.
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DOI：
10.1289/ehp.7737
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发表时间：
2005-07
影响因子：
10.4
通讯作者：
Stone PH
中科院分区：
文献类型：
--
作者：
Gold DR;Litonjua AA;Zanobetti A;Coull BA;Schwartz J;MacCallum G;Verrier RL;Nearing BD;Canner MJ;Suh H;Stone PH
每日环境颗粒污染水平的增加与心血管发病率的增加有关。黑碳（BC）是衡量交通相关颗粒成分的指标。我们在一项重复测量研究中调查了环境污染与st段水平之间的关系，该研究包括对24名61-88岁活跃的波士顿居民的269次观察，每个人从1999年6月到9月观察了12次。该方案包括连续动态心电图监测，包括5分钟休息、5分钟站立、5分钟户外运动、5分钟恢复和20个周期的有节奏呼吸。据估计，与污染相关的st段低洼区在卑诗省有10 - 90个百分位数的变化。我们计算了平均st段水平，参考P-R等电值，为协议的每个部分。测试前12小时的平均BC水平和测试前5小时的BC水平在大多数情况下预测st段抑郁，但在运动后阶段效果最强。在连续模型中，在运动后休息期间，BC水平升高与- 0.1 mm st段下降相关（12小时平均BC p = 0.02； 5小时BC p = 0.001）。升高的BC也预示着st段凹陷≥0.5 mm至少有一次发作的st段凹陷的风险增加。一氧化碳并不是这种联系的干扰因素。st段凹陷，可能代表心肌缺血或炎症，与主要来源为交通的颗粒暴露增加有关。
Increased levels of daily ambient particle pollution have been associated with increased risk of cardiovascular morbidity. Black carbon (BC) is a measure of the traffic-related component of particles. We investigated associations between ambient pollution and ST-segment levels in a repeated-measures study including 269 observations on 24 active Boston residents 61–88 years of age, each observed up to 12 times from June through September 1999. The protocol involved continuous Holter electrocardiogram monitoring including 5 min of rest, 5 min of standing, 5 min of exercise outdoors, 5 min of recovery, and 20 cycles of paced breathing. Pollution-associated ST-depression was estimated for a 10th- to 90th-percentile change in BC. We calculated the average ST-segment level, referenced to the P-R isoelectric values, for each portion of the protocol. The mean BC level in the previous 12 hr, and the BC level 5 hr before testing, predicted ST-segment depression in most portions of the protocol, but the effect was strongest in the postexercise periods. During post-exercise rest, an elevated BC level was associated with −0.1 mm ST-segment depression (p = 0.02 for 12-hr mean BC; p = 0.001 for 5-hr BC) in continuous models. Elevated BC also predicted increased risk of ST-segment depression ≥0.5 mm among those with at least one episode of that level of ST-segment depression. Carbon monoxide was not a confounder of this association. ST-segment depression, possibly representing myocardial ischemia or inflammation, is associated with increased exposure to particles whose predominant source is traffic.
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影响因子：
168.9
作者：
Peters, A;Doring, A;Koenig, W
通讯作者：
Koenig, W
影响因子：
158.5
作者：
Frolkis, JP;Pothier, CE;Lauer, MS
通讯作者：
Lauer, MS
影响因子：
10.4
作者：
Liao, DP;Creason, J;Zweidinger, R
通讯作者：
Zweidinger, R
影响因子：
2.1
作者：
POPE, CA;DOCKERY, DW;SCHWARTZ, J
通讯作者：
SCHWARTZ, J
影响因子：
2.8
作者：
LANZA, GA;MASCELLANTI, M;MASERI, A
通讯作者：
MASERI, A