Responsiveness to exercise training in juvenile dermatomyositis: a twin case study.
Responsiveness to exercise training in juvenile dermatomyositis: a twin case study.
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DOI：
10.1186/1471-2474-11-270
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发表时间：
2010-11-25
影响因子：
2.3
通讯作者：
Silva CA
中科院分区：
文献类型：
--
作者：
Omori C;Prado DM;Gualano B;Sallum AM;Sá-Pinto AL;Roschel H;Perondi MB;Silva CA
青少年皮肌炎（JDM）患者经常表现出强烈的运动不耐受和肌无力。然而，运动训练在这种疾病中的作用尚未得到研究。本纵向病例研究报告了运动训练对一名7岁的JDM患者及其未受影响的同卵双胞胎姐妹（作为对照）的影响。被诊断患有JDM的患者以及她的健康双胞胎都接受了为期16周的运动训练计划，包括有氧运动和强化运动。我们评估了一次重复最大（1-RM）腿部推举和卧推力量，平衡，移动性和肌肉功能，炎症和肌肉酶的血液标志物，有氧条件反射和疾病活动评分。结果，在基线和试验后，与她的JDM双胞胎相比，健康儿童具有更大的绝对力量，肌肉功能和有氧条件反射。然而，双胞胎在1-RM卧推、1-RM腿部推举、VO 2峰值和力竭时间方面表现出可比的相对改善。健康儿童有更大的相对增量在下背部力量和握力，而儿童与JDM提出了一个较高的相对增加的解释性无氧阈值参数和功能测试。生活质量、炎症、肌肉损伤和疾病活动度评分保持不变。这是第一份描述非活动性JDM患者在运动训练方案后的训练反应的报告。患有JDM的儿童表现出改善的力量，肌肉功能和有氧条件反射，而没有表现出疾病的恶化。
Patients with juvenile dermatomyositis (JDM) often present strong exercise intolerance and muscle weakness. However, the role of exercise training in this disease has not been investigated. this longitudinal case study reports on the effects of exercise training on a 7-year-old patient with JDM and on her unaffected monozygotic twin sister, who served as a control. Both the patient who was diagnosed with JDM as well as her healthy twin underwent a 16-week exercise training program comprising aerobic and strengthening exercises. We assessed one repetition-maximum (1-RM) leg-press and bench-press strength, balance, mobility and muscle function, blood markers of inflammation and muscle enzymes, aerobic conditioning, and disease activity scores. As a result, the healthy child had an overall greater absolute strength, muscle function and aerobic conditioning compared to her JDM twin pair at baseline and after the trial. However, the twins presented comparable relative improvements in 1-RM bench press, 1-RM leg press, VO2peak, and time-to-exhaustion. The healthy child had greater relative increments in low-back strength and handgrip, whereas the child with JDM presented a higher relative increase in ventilatory anaerobic threshold parameters and functional tests. Quality of life, inflammation, muscle damage and disease activity scores remained unchanged. this was the first report to describe the training response of a patient with non-active JDM following an exercise training regimen. The child with JDM exhibited improved strength, muscle function and aerobic conditioning without presenting an exacerbation of the disease.
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DOI：
10.1590/s1516-31802000000200002
发表时间：
2000-03-02
期刊：
Sao Paulo medical journal = Revista paulista de medicina
影响因子：
--
作者：
Hilario, M O;Yamashita, H;Lederman, H
通讯作者：
Lederman, H
影响因子：
1.4
作者：
Sallum, Adriana Maluf Elias;Kiss, Maria Helena Bittencurt;Marie, Suely Kazue Nagahashi
通讯作者：
Marie, Suely Kazue Nagahashi
影响因子：
3.5
作者：
Arnardottir, S;Alexanderson, H;Borg, K
通讯作者：
Borg, K
影响因子：
3.3
作者：
Sallum, Adriana M. E.;Pivato, Francine C. M. M.;Silva, Clovis A. A.
通讯作者：
Silva, Clovis A. A.
DOI：
10.1002/art.21332
发表时间：
2005-08-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Maillard, SM;Jones, R;Murray, KJ
通讯作者：
Murray, KJ