Chronically Maternal Exposure to Fenvalerate during Medium-Late Pregnancy Accelerated Cognitive Decline in Middle-Aged Offspring Mice
Chronically Maternal Exposure to Fenvalerate during Medium-Late Pregnancy Accelerated Cognitive Decline in Middle-Aged Offspring Mice
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母亲在中晚期妊娠期间长期接触氰戊菊酯会加速中年子代小鼠的认知衰退
DOI：
10.15379/2409-3564.2014.01.01.4
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
De-Xiang Xu
中科院分区：
文献类型：
--
作者：
Fang Wang;Gui-Hai Chen;Xue-Wei Li;Qi-Gang Yang;Yan He;Hua Wang;De-Xiang Xu
流行病学证据表明，农药暴露可能参与阿尔茨海默病（AD）的发病机制。然而，母亲暴露于氰戊菊酯（FV）是否会影响中年后代的AD型行为尚未确定。在本研究中，CD-1母体在妊娠第8-18天每天通过管饲法接受7.5 mg/kg FV或玉米油。在4-34周龄时记录后代的体重。在13个月时进行一系列行为任务，并将5个月大的小鼠设置为年轻对照。结果表明，FV处理组小鼠的体重与对照组相比无显著差异。与年轻小鼠相比，中年对照小鼠表现出减少的穴居活动，减少自发探索和感觉运动能力，增加焦虑，空间和非空间学习和记忆能力受损。与对照组相比，FV处理的小鼠表现出相似的物种典型行为，运动活动，感觉运动能力，但焦虑增加，学习和记忆能力下降。本研究结果提示，母亲在妊娠中晚期长期暴露低剂量FV，可加速发育正常的中年子代学习记忆行为和焦虑行为的损害。
Epidemiological evidence suggests that pesticide exposure may be involved in the pathogenesis of Alzheimer's disease (AD). However, whether maternal exposure to fenvalerate (FV) can affect AD-type behaviors in middle-aged offspring has not been determined yet. In this study, CD-1 mothers received 7.5 mg/kg FV or corn oil by gavage daily during gestational days 8-18. Body weight of the offspring was recorded at ages 4-34 weeks. A battery of behavioral tasks was conducted at 13-month, and 5-month-old mice were set as a young control. The results showed that there was insignificant difference in body weight between the FV-treated and control mice. Compared to the young mice, the middle-aged control mice exhibited decreased burrowing activity, decreased spontaneous exploration and sensorimotor ability, increased anxiety, and impaired abilities of spatial and non-spatial learning and memory. Compared to the controls, the FV-treated mice exhibited similar species-typical behaviors, locomotor activity, sensorimotor abilities, but increased anxiety, and decreased abilities of learning and memory. Our results suggested that chronically maternal exposure to FV at a low dose in medium-late gestation could accelerate the impairment in the behaviors of learning and memory and anxiety in the middle-aged offspring, which experience a normal duration of development.
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DOI：
10.1186/alzrt182
发表时间：
2013
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Webster SJ;Bachstetter AD;Van Eldik LJ
通讯作者：
Van Eldik LJ
影响因子：
3
作者：
Morley, R
通讯作者：
Morley, R
影响因子：
4.5
作者：
I. Zaganas;Stefania Kapetanaki;V. Mastorodemos;K. Kanavouras;C. Colosio;M. Wilks;A. Tsatsakis
通讯作者：
I. Zaganas;Stefania Kapetanaki;V. Mastorodemos;K. Kanavouras;C. Colosio;M. Wilks;A. Tsatsakis
影响因子：
8.3
作者：
Kyle Steenland;C. Wesseling;Norbel Román;Indiana Quirós;Jorge L. Juncos
通讯作者：
Kyle Steenland;C. Wesseling;Norbel Román;Indiana Quirós;Jorge L. Juncos
影响因子：
2.9
作者：
Braquenier, Jean-Baptiste;Quertemont, Etienne;Plumier, Jean-Christophe
通讯作者：
Plumier, Jean-Christophe