Intravitreous fibronectin and platelet-derived growth factor. New model for traction retinal detachment.
Intravitreous fibronectin and platelet-derived growth factor. New model for traction retinal detachment.
复制标题
玻璃体内纤连蛋白和血小板衍生生长因子。
DOI：
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
B. Glaser
中科院分区：
文献类型：
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作者：
J. Yeo;J. Sadeghi;P. Campochiaro;W. Green;B. Glaser
在增殖性玻璃体视网膜病变和创伤中，牵引性视网膜脱离是由于细胞迁移到玻璃体腔并形成收缩膜所致。 Cleary 和 Ryan 已经确定了玻璃体内注射自体血液在兔眼中重现这种病理过程的功效。先前已表明，两种血清成分，纤连蛋白和血小板衍生生长因子，可刺激细胞迁移。我们现在发现，玻璃体内注射纤连蛋白和血小板衍生生长因子后三周内，72% 的兔眼会发生收缩膜和牵拉性视网膜脱离。这些结果为研究玻璃体内细胞膜和牵引性视网膜脱离的发展提供了一个简单的新模型。
In proliferative vitreoretinopathy and trauma, traction retinal detachments result from cellular migration into the vitreous cavity with contractile membrane formation. Cleary and Ryan have established the efficacy of intravitreous injection of autologous blood in reproducing this pathologic process in the rabbit eye. It has previously been shown that two serum components, fibronectin and platelet-derived growth factor, stimulate cellular migration. We now show that contractile membranes and traction retinal detachments occur in 72% of rabbit eyes within three weeks following intravitreous injection of fibronectin and platelet-derived growth factor. These results provide a straightforward new model to study the development of intravitreous cellular membranes and traction retinal detachments.
影响因子：
4.2
作者：
N. Radtke;Yasuo Tano;David B. Chandler;R. Machemer
通讯作者：
N. Radtke;Yasuo Tano;David B. Chandler;R. Machemer
影响因子：
4.2
作者：
FASTENBERG, DM;DIDDIE, KR;RYAN, SJ
通讯作者：
RYAN, SJ