Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation.
Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation.
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中草药表观遗传学研究：DNA 甲基化的多效性作用
DOI：
10.3389/fphar.2021.790321
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发表时间：
2021
影响因子：
5.6
通讯作者：
Yuan CS
中科院分区：
文献类型：
--
作者：
Guo W;Ma H;Wang CZ;Wan JY;Yao H;Yuan CS
DNA甲基化参与了许多细胞过程和多种人类疾病，但很少有研究涉及DNA甲基化在中草药中的多效性作用。CHM已在全球范围内用于预防和治疗多种疾病。新兴的表观遗传学技术为中药的发展带来了巨大的机遇。本文综述了DNA甲基化的研究进展，并阐述了DNA甲基化在中医药中的多效性作用。DNA甲基化作为一种介导因子参与植物对环境因子的反应，从而影响中药药用植物的生长和生物活性物质的合成，这对中药的疗效至关重要。此外，DNA甲基化有助于揭示中药配方，草药和草药衍生化合物的药物机制。为构成理论和中医药的基本问题提供了科学依据。DNA甲基化这一新发展的领域正在解决CHM的许多复杂的科学问题;因此，它不仅促进疾病治疗，而且有利于健康维护。
Accumulating knowledge has been achieved on DNA methylation participating in numerous cellular processes and multiple human diseases; however, few studies have addressed the pleiotropic role of DNA methylation in Chinese herbal medicine (CHM). CHM has been used worldwide for the prevention and treatment of multiple diseases. Newly developed epigenetic techniques have brought great opportunities for the development of CHM. In this review, we summarize the DNA methylation studies and portray the pleiotropic role of DNA methylation in CHM. DNA methylation serves as a mediator participating in plant responses to environmental factors, and thus affecting CHM medicinal plants growth and bioactive compound biosynthesis which are vital for therapeutic effects. Furthermore, DNA methylation helps to uncover the pharmaceutical mechanisms of CHM formulae, herbs, and herbal-derived compounds. It also provides scientific validation for constitution theory and other essential issues of CHM. This newly developed field of DNA methylation is up-and-coming to address many complicated scientific questions of CHM; it thus not only promotes disease treatment but also facilitates health maintenance.
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DOI：
10.1093/ecam/neq050
发表时间：
2011
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Hsieh HY;Chiu PH;Wang SC
通讯作者：
Wang SC
影响因子：
3.7
作者：
Gong Y;Li Y;Abdolmaleky HM;Li L;Zhou JR
通讯作者：
Zhou JR
影响因子：
4
作者：
Kedaigle A;Fraenkel E
通讯作者：
Fraenkel E
影响因子：
5.6
作者：
Guo Q;Zheng K;Fan D;Zhao Y;Li L;Bian Y;Qiu X;Liu X;Zhang G;Ma C;He X;Lu A
通讯作者：
Lu A
影响因子：
4.7
作者：
Bano N;Yadav M;Das BC
通讯作者：
Das BC