Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.
Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.
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DOI：
10.1016/j.ydbio.2014.03.004
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发表时间：
2014-06-01
影响因子：
2.7
通讯作者：
Groves, Andrew K.
中科院分区：
文献类型：
--
作者：
Edlund, Renee K.;Ohyama, Takahiro;Kantarci, Husniye;Riley, Bruce B.;Groves, Andrew K.
脊椎动物面部的骨骼由短暂存在的胚胎鳃弓发育而来，这些鳃弓中有颅神经嵴细胞。我们对叉头家族转录因子Foxi3的一个小鼠突变体进行了特征分析，该因子在鳃外胚层和内胚层中表达。Foxi3突变小鼠无法存活，并表现出严重的由鳃弓衍生的面部骨骼缺陷，包括除下颌骨最远端尖端外全部缺失，以及内耳、中耳和外耳结构完全缺失。尽管Foxi3突变体的颅神经嵴细胞能够迁移、定殖于鳃弓并显示出一些正确的近 - 远轴模式化的要素，但从胚胎第9.75天起它们就会发生凋亡。我们表明这种细胞死亡与鳃弓外胚层中Fgf8表达的延迟以及鳃弓中的神经嵴细胞无法表达成纤维细胞生长因子（FGF）应答基因相关。斑马鱼的foxi1也在鳃弓外胚层和内胚层中表达，并且foxi1的吗啉代寡核苷酸敲低也会导致鳃弓中神经嵴细胞的凋亡。我们表明在斑马鱼鳃弓组织中热激诱导fgf3能够挽救foxi1吗啉代寡核苷酸敲低胚胎中的细胞死亡。我们的研究结果表明，Foxi3可能在鳃弓中信号中心的建立过程中发挥作用，而这些信号中心对于神经嵴的存活、模式化以及鳃弓衍生物的后续发育是必需的。
The bones of the vertebrate face develop from transient embryonic branchial arches that are populated by cranial neural crest cells. We have characterized a mouse mutant for the Forkhead family transcription factor Foxi3, which is expressed in branchial ectoderm and endoderm. Foxi3 mutant mice are not viable and display severe branchial arch-derived facial skeleton defects, including absence of all but the most distal tip of the mandible and complete absence of the inner, middle and external ear structures. Although cranial neural crest cells of Foxi3 mutants are able to migrate, populate the branchial arches and display some elements of correct proximo distal patterning, they succumb to apoptosis from embryonic day 9.75 onwards. We show this cell death correlates with a delay in expression of Fgf8 in branchial arch ectoderm and a failure of neural crest cells in the arches to express FGF responsive genes. Zebrafish foxi1 is also expressed in branchial arch ectoderm and endoderm, and morpholino knockdown of foxi1 also causes apoptosis of neural crest in the branchial arches. We show that heat shock induction of fgf3 in zebrafish arch tissue can rescue cell death in foxi1 morphants. Our results suggest that Foxi3 may play a role in the establishment of signaling centers in the branchial arches that are required for neural crest survival, patterning and the subsequent development of branchial arch derivatives.
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影响因子：
2.7
作者：
Millimaki BB;Sweet EM;Riley BB
通讯作者：
Riley BB
DOI：
10.1016/j.gep.2009.04.002
发表时间：
2009-06
期刊：
Gene expression patterns : GEP
影响因子：
--
作者：
Danesh SM;Villasenor A;Chong D;Soukup C;Cleaver O
通讯作者：
Cleaver O
影响因子：
2.6
作者：
Brewer, S;Jiang, XB;Sucov, HM
通讯作者：
Sucov, HM
影响因子：
11.8
作者：
Marinic, Mirna;Aktas, Tugce;Spitz, Francois
通讯作者：
Spitz, Francois
DOI：
10.1073/pnas.0604751103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Brito, Jose M.;Teillett, Marie-Aimee;Le Douarin, Nicole M.
通讯作者：
Le Douarin, Nicole M.