BMP and BMP receptor expression during murine organogenesis.
BMP and BMP receptor expression during murine organogenesis.
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DOI：
10.1016/j.gep.2009.04.002
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Cleaver O
中科院分区：
文献类型：
--
作者：
Danesh SM;Villasenor A;Chong D;Soukup C;Cleaver O
细胞 - 细胞通信对于确定胚胎器官的生长和分化至关重要在某些组织中无数BMP配体和接收器之间的高冗余性，使用单个靶向单一靶向来解决BMP信号的作用受到挑战小鼠模型中的BMP基因。 ），在鼠器官发生的初始步骤中，在早期的胚胎中，我们专注于在胚胎发生期间形成的第一个器官和组织中BMP家族成员的表达作为心脏，肺部，肝脏，神经系统，四肢和肢体的心脏，我们在特定的组织中识别出单独或同时表达配体的域在肠道中构成肠道中的BMP4的先前未知的不对称表达，该表达在肠道转弯之前启动，并在胃肠道中建立器官不对称。未来的设计和/或解释单个BMP或BMPR基因的目标缺失，因为本研究确定了可能发生冗余BMP信号通路的器官和组织。
Cell-cell communication is critical for regulating embryonic organ growth and differentiation. The Bone Morphogenetic Protein (BMP) family of transforming growth factor β (TGFβ) molecules represents one class of such cell-cell signaling molecules that regulate the morphogenesis of several organs. Due to high redundancy between the myriad BMP ligands and receptors in certain tissues, it has been challenging to address the role of BMP signaling using targeting of single Bmp genes in mouse models. Here, we present a detailed study of the developmental expression profiles of three BMP ligands (Bmp2, Bmp4, Bmp7) and three BMP receptors (Bmpr1a, Bmpr1b, and BmprII), as well as their molecular antagonist (noggin), in the early embryo during the initial steps of murine organogenesis. In particular, we focus on the expression of Bmp family members in the first organs and tissues that take shape during embryogenesis, such as the heart, vascular system, lungs, liver, stomach, nervous system, somites and limbs. Using in situ hybridization, we identify domains where ligand(s) and receptor(s) are either singly or co-expressed in specific tissues. In addition, we identify a previously unnoticed asymmetric expression of Bmp4 in the gut mesogastrium, which initiates just prior to gut turning and the establishment of organ asymmetry in the gastrointestinal tract. Our studies will aid in the future design and/or interpretation of targeted deletion of individual Bmp or Bmpr genes, since this study identifies organs and tissues where redundant BMP signaling pathways are likely to occur.
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影响因子：
2.5
作者：
Christoffels, VM;Hoogaars, WMH;Campione, M
通讯作者：
Campione, M
影响因子：
2.6
作者：
LYONS, KM;HOGAN, BLM;ROBERTSON, EJ
通讯作者：
ROBERTSON, EJ
影响因子：
4.6
作者：
Pajni-Underwood, Sangeeta;Wilson, Catherine P.;Lewandoski, Mark
通讯作者：
Lewandoski, Mark
影响因子：
1.5
作者：
Kulessa, H;Hogan, BLM
通讯作者：
Hogan, BLM
DOI：
10.1006/bbrc.1997.6816
发表时间：
1997-06-27
影响因子：
3.1
作者：
Beppu, H;Minowa, O;Kawabata, M
通讯作者：
Kawabata, M