Airway response to electrical field stimulation in sensitized inbred mice. Passive transfer of increased responsiveness with peribronchial lymph nodes.
Airway response to electrical field stimulation in sensitized inbred mice. Passive transfer of increased responsiveness with peribronchial lymph nodes.
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致敏近交系小鼠对电场刺激的气道反应。
DOI：
10.1172/jci115651
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Gelfand,EW
中科院分区：
文献类型：
--
作者：
Larsen,GL;Renz,H;Loader,JE;Bradley,KL;Gelfand,EW
我们研究了反复暴露于抗原对两种近交系小鼠对胆碱能刺激的气道反应的影响，这两种近交系小鼠在潜在的胆碱能气道反应方面相似，但在产生IgE的能力上不同。BALB/c和SJL/J小鼠均通过吸入卵清蛋白重复暴露10d。虽然BALB/c小鼠产生了这种过敏原的IgE抗体，但SJL/J株未能产生明显的IgE反应。对两种品系暴露于盐水中的小鼠(对照组)的气管平滑肌反应的体外评估显示，对乙酰甲胆碱和电场刺激的反应在两种品系之间没有显著差异。暴露于卵清蛋白后，BALB/c株对电场刺激的反应显著增强，而对乙酰甲胆碱的反应不变。相比之下，SJL/J小鼠在吸入雾化卵清蛋白后，对这些刺激的体外反应性并没有增加。被动地将卵蛋白致敏的BALB/c小鼠的支气管周围淋巴结中的细胞转移到同基因非免疫小鼠中，也导致了气管平滑肌对电场刺激的反应性增加。相反，来自非致敏小鼠的细胞转移并没有改变反应性。这些结果表明，能够对变应原产生IgE反应的小鼠物种也会在其呼吸道的神经控制方面发生变化。此外，这种改变似乎是依赖于淋巴细胞的，因为在过敏原暴露后，在支气管周围淋巴结内发现的细胞能够将这种反应性的增加转移到非免疫小鼠。
We have examined the effects of repeated exposure to antigen on airway responses to cholinergic stimulation in two inbred strains of mice that are similar in underlying cholinergic airway responsiveness, yet differ in their ability to produce IgE. Both BALB/c and SJL/J mice were repeatedly exposed to ovalbumin by inhalation for a 10-d period. While the BALB/c mice developed IgE antibody to this allergen, the SJL/J strain failed to mount an appreciable IgE response. In vitro assessments of the response of tracheal smooth muscle from saline exposed mice (controls) of both strains demonstrated responses to both methacholine and electrical field stimulation that were not significantly different between the strains. Following exposure to ovalbumin, the BALB/c strain developed a significant increase in their response to electrical field stimulation, while their response to methacholine was unaltered. In contrast, the in vitro responsiveness to these stimuli did not increase in SJL/J mice following similar exposure to inhaled nebulized ovalbumin. The passive transfer of cells from the peribronchial lymph nodes of ovalbumin-sensitized BALB/c mice into syngeneic nonimmune mice also led to increases in responsiveness of tracheal smooth muscle to electrical field stimulation. In contrast, transfer of cells from nonsensitized mice did not alter responsiveness. These results suggest that murine species capable of developing an IgE response to allergen also develop alterations in the neural control of their airways. Further, this alteration appears to be lymphocyte dependent, in that cells found within peribronchial lymph nodes following allergen exposure are capable of transferring this increase in responsiveness to nonimmune mice.
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影响喷射雾化器气溶胶粒径分布的因素。
影响因子：
10
作者：
M. Clay;D. Pavia;S. Newman;S. Clarke
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晚期哮喘反应的昼夜节律基础。
DOI：
10.1164/ajrccm/142.5.1153
发表时间：
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期刊：
The American review of respiratory disease
影响因子：
--
作者：
Mohiuddin,AA;Martin,RJ
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Martin,RJ
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DOI：
10.1164/arrd.1986.134.1.62
发表时间：
1986
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Murphy,KR;Wilson,MC;Irvin,CG;Glezen,LS;Marsh,WR;Haslett,C;Henson,PM;Larsen,GL
通讯作者：
Larsen,GL
影响因子：
3.3
作者：
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DOI：
10.1159/000230343
发表时间：
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期刊：
International archives of allergy and applied immunology
影响因子：
--
作者：
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通讯作者：
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