Age, kidney function, and risk factors associate differently with cortical and medullary volumes of the kidney.
Age, kidney function, and risk factors associate differently with cortical and medullary volumes of the kidney.
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DOI：
10.1038/ki.2013.359
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发表时间：
2014-03
影响因子：
19.6
通讯作者：
Rule, Andrew D.
中科院分区：
文献类型：
--
作者：
Wang, Xiangling;Vrtiska, Terri J.;Avula, Ramesh T.;Walters, Leah R.;Chakkera, Harini A.;Kremers, Walter K.;Lerman, Lilach O.;Rule, Andrew D.
晚期慢性肾脏病(CKD)患者的肾脏萎缩，但影响正常成人肾脏大小的因素尚不清楚。为了帮助确定这一点，我们测量了1344名潜在肾脏捐赠者(年龄在18至75岁)的增强CT图像上的肾脏体积。单位体表面积的皮质体积在两性中随着年龄的增长而逐渐下降。从统计学上讲，这主要取决于与年龄相关的肾小球滤过率(GFR)的下降。单位体表面积皮质体积增加的独立预测因素是男性、GFR增加、24小时尿白蛋白增加、当前吸烟者和降低高密度脂蛋白胆固醇。男性的单位体表面积的髓质体积随着年龄的增长而增加，而女性的每一身体表面积的髓质体积随着年龄的增长而增加，直到50岁，然后下降。每体表面积髓体积增加的独立预测因素是年龄、男性、肾小球滤过率增加、24小时尿白蛋白增加、血糖增加和血尿酸降低。因此，虽然皮质体积随着年龄的增长而下降，但与与年龄相关的GFR和蛋白尿下降的生物学途径相同，一些CKD危险因素实际上与相对健康的成年人皮质或髓质体积的增加有关。不同肾单位区域潜在的肥大或萎缩可以解释这些发现。
The kidney atrophies in patients with advanced chronic kidney disease (CKD) but factors influencing kidney size in normal adults are less clear. To help define this we measured kidney volumes on contrast-enhanced CT images from 1344 potential kidney donors (ages 18 to 75 years). Cortical volume per body surface area progressively declined in both genders with increased age. Statistically, this was primarily dependent on the age-related decline in glomerular filtration rate (GFR). Independent predictors of increased cortical volume per body surface area were male gender, increased GFR, increased 24-hour urine albumin, current smoker, and decreased high-density lipid cholesterol. Medullary volume per body surface area increased with age in men while it increased with age in women until age 50 followed by a subsequent decline. Independent predictors of increased medullary volume per body surface area were older age, male gender, increased GFR, increased 24-hour urine albumin, increased serum glucose, and decreased serum uric acid. Thus, while cortical volume declines with age along the same biological pathway as the age-related decline in GFR and albuminuria some CKD risk factors are actually associated with increased cortical or medullary volume among relatively healthy adults. Underlying hypertrophy or atrophy of different nephron regions may explain these findings.
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影响因子：
5
作者：
EMAMIAN, SA;NIELSEN, MB;YTTE, L
通讯作者：
YTTE, L
影响因子：
6.5
作者：
Krikken, Jan A.;Gansevoort, Ron T.;Dullaart, Robin P. F.
通讯作者：
Dullaart, Robin P. F.
影响因子：
19.6
作者：
Kambham, N;Markowitz, GS;D'Agati, VD
通讯作者：
D'Agati, VD
影响因子：
19.6
作者：
Bosma, RJ;van der Heide, JJH;Navis, G
通讯作者：
Navis, G
DOI：
10.1007/bf00335505
发表时间：
1969-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
DARNTON, SJ
通讯作者：
DARNTON, SJ