Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging.
Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging.
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DOI：
10.3109/13697137.2011.650656
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
STRAW+10 Collaborative Group
中科院分区：
文献类型：
--
作者：
Harlow SD;Gass M;Hall JE;Lobo R;Maki P;Rebar RW;Sherman S;Sluss PM;de Villiers TJ;STRAW+10 Collaborative Group
总结对2001年生殖老化阶段研讨会（STages of Reproductive Aging Workshop，简称STW）标准的建议更新。2011年10月10日的研讨会回顾了对末次月经前后下丘脑-垂体-卵巢功能关键变化的理解进展。来自五个国家和多个学科的科学家评估了中年妇女队列研究的数据，并在慢性疾病和内分泌疾病的背景下，对生殖衰老的月经，内分泌和卵巢标志物的变化进行了评估，包括抗苗勒管激素（AMH），卵泡刺激素B，卵泡刺激素（FSH）和窦卵泡计数（AFC）。修改意见以协商一致方式获得通过。绝经早期和晚期过渡期的10项简化出血标准，建议修改生殖晚期标准（第-3期）和绝经后早期（第+1期），提供了关于晚期过渡（第-1期）和绝经后早期（第+1期）的持续时间的信息，并建议无论妇女的年龄、种族、体型或生活方式特征如何都应使用。2010年为在研究和临床背景下评估生殖老化提供了更全面的基础。10 +10分期系统的应用应提高中年妇女研究的可比性，并促进临床决策。尽管如此，重要的知识差距仍然存在，并确定了七个研究重点。
To summarize recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW+10 workshop reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period (FMP). Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders, on change in menstrual, endocrine and ovarian markers of reproductive aging including anti-mullerian hormone (AMH), inhibin B, follicle-stimulating hormone (FSH), and antral follicle count (AFC). Modifications were adopted by consensus. STRAW+10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage − 3) and the early post-menopause stage (Stage +1), provided information on the duration of the late transition (Stage −1) and early post-menopause (Stage +1) and recommended application regardless of women’s age, ethnicity, body size or lifestyle characteristics. STRAW+10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW+10 staging system should improve comparability of studies of midlife women and facilitate clinical decision-making. Nonetheless, important knowledge gaps persist and seven research priorities are identified.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
6.7
作者：
Dennerstein, L;Dudley, E;Burger, H
通讯作者：
Burger, H
影响因子：
6.7
作者：
Gelbaya, Tarek A.;Nardo, Luciano G.;Lieberman, Brian A.
通讯作者：
Lieberman, Brian A.
影响因子：
--
作者：
Bromberger, Joyce T.;Schott, Laura L.;Kravitz, Howard M.;Sowers, MaryFran;Avis, Nancy E.;Gold, Ellen B.;Randolph, John F., Jr.;Matthews, Karen A.
通讯作者：
Matthews, Karen A.
影响因子：
6.1
作者：
Elting, MW;Korsen, TJM;Schoemaker, J
通讯作者：
Schoemaker, J