Specification of neural crest into sensory neuron and melanocyte lineages.
Specification of neural crest into sensory neuron and melanocyte lineages.
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DOI：
10.1016/j.ydbio.2012.02.038
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发表时间：
2012-06-01
影响因子：
2.7
通讯作者：
Raible DW
中科院分区：
文献类型：
--
作者：
Pavan WJ;Raible DW
阐明多能细胞分化成不同谱系的机制是发育生物学研究的一个共同主题。在理解神经嵴不同谱系的特化所涉及的一些基本因素和途径方面取得了进展。这些包括基因调控网络，涉及转录因子的层次结构和输入信号通路介导的环境线索。本文就神经嵴的外周感觉神经元和黑色素细胞两个谱系的机制进行综述。深入了解这些细胞类型的规格可能会揭示在整个开发过程中发生的规格过程中的共同主题。
Elucidating the mechanisms by which multipotent cells differentiate into distinct lineages is a common theme underlying developmental biology investigations. Progress has been made in understanding some of the essential factors and pathways involved in the specification of different lineages from the neural crest. These include gene regulatory networks involving transcription factor hierarchies and input from signaling pathways mediated from environmental cues. In this review, we examine the mechanisms for two lineages that are derived from neural crest, the peripheral sensory neurons and the pigment producing melanocytes. Insights into the specification of these cell types may reveal common themes in the specification processes that occur throughout development.
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