Early diagnosis of disease using microbead array technology: A review.
Early diagnosis of disease using microbead array technology: A review.
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DOI：
10.1016/j.aca.2018.05.011
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发表时间：
2018-11-22
影响因子：
6.2
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
Parsa SF;Vafajoo A;Rostami A;Salarian R;Rabiee M;Rabiee N;Rabiee G;Tahriri M;Yadegari A;Vashaee D;Tayebi L;Hamblin MR
疾病的早期诊断（在疾病发展到晚期和无法治愈之前）对于降低发病率和死亡率至关重要。随着临床实验室诊断新技术的出现，基于微珠的阵列已被认为是一种有效的方法，与传统的多种疾病相关生物标志物检测方法相比，它具有明显的优势。多重微珠测定提供了一种稳健、快速、特异且经济高效的方法，用于高通量和同时筛选许多不同的靶标。将含有目标分析物的生物样品（例如血浆、唾液、脑脊液等）施加到一组具有不同配体特异性（已编码在平面或悬浮阵列中）的微珠后，会发生生物分子结合相互作用。配体-受体结合活性通过在悬浮阵列的情况下通过流式细胞术分析产生的光信号进行跟踪，或者在平面阵列的情况下通过图像处理装置产生。在这篇综述论文中，我们讨论了通过使用基于光学编码微珠的阵列（多重分析和单一分析物测定）作为检测和定量各种分析物的可靠工具来诊断癌症、神经系统和传染病。
Early diagnosis of diseases (before they become advanced and incurable) is essential to reduce morbidity and mortality rates. With the advent of novel technologies in clinical laboratory diagnosis, microbead-based arrays have come to be recognized as an efficient approach, that demonstrates useful advantages over traditional assay methods for multiple disease-related biomarkers. Multiplexed microbead assays provide a robust, rapid, specific, and cost-effective approach for high-throughput and simultaneous screening of many different targets. Biomolecular binding interactions occur after applying a biological sample (such as blood plasma, saliva, cerebrospinal fluid etc.) containing the target analyte(s) to a set of microbeads with different ligand-specificities that have been coded in planar or suspension arrays. The ligand-receptor binding activity is tracked by optical signals generated by means of flow cytometry analysis in the case of suspension arrays, or by image processing devices in the case of planar arrays. In this review paper, we discuss diagnosis of cancer, neurological and infectious diseases by using optically-encoded microbead-based arrays (both multiplexed and single-analyte assays) as a reliable tool for detection and quantification of various analytes.
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影响因子：
17.1
作者：
Choi, Inhee;Lee, Luke P.
通讯作者：
Lee, Luke P.
影响因子：
4
作者：
Chen, Rui;Snyder, Michael
通讯作者：
Snyder, Michael
DOI：
10.1016/j.nano.2015.03.003
发表时间：
2015-07-01
影响因子：
5.4
作者：
Brazhnik, Kristina;Sokolova, Zinaida;Sukhanova, Alyona
通讯作者：
Sukhanova, Alyona
影响因子：
3.5
作者：
Anstey, Kaarin J.;Cherbuin, Nicolas;Herath, Pushpani M.
通讯作者：
Herath, Pushpani M.
DOI：
10.1128/cdli.10.1.133-139.2003
发表时间：
2003-01-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
de Jager, W;te Velthuis, H;Rijkers, GT
通讯作者：
Rijkers, GT