New Molecular Players in the Development of Callosal Projections.
New Molecular Players in the Development of Callosal Projections.
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DOI：
10.3390/cells10010029
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发表时间：
2020-12-26
期刊：
影响因子：
6
通讯作者：
Torii M
中科院分区：
文献类型：
--
作者：
Ku RY;Torii M
人类的大脑皮层发育是一个长期持续的过程，它会不断地修改神经回路，直到青春期。胼胝体（大脑中最大的白色物质束）的动态成熟很好地代表了这一点。胼胝体投射神经元的长距离轴突形成的胼胝体的主要组成部分是相对最近的进化与大量的，不成比例的增加，在人类。虽然胼胝体的解剖结构及其发育过程的细胞过程在过去的几十年里已经被各个领域的专家深入研究，但其发育的整体图景，特别是胼胝体投射发育的分子控制，仍然有许多缺失。本文综述了胼胝体形成的最新进展，特别强调了胼胝体轴突投射发展的新分子球员。
Cortical development in humans is a long and ongoing process that continuously modifies the neural circuitry into adolescence. This is well represented by the dynamic maturation of the corpus callosum, the largest white matter tract in the brain. Callosal projection neurons whose long-range axons form the main component of the corpus callosum are evolved relatively recently with a substantial, disproportionate increase in numbers in humans. Though the anatomy of the corpus callosum and cellular processes in its development have been intensively studied by experts in a variety of fields over several decades, the whole picture of its development, in particular, the molecular controls over the development of callosal projections, still has many missing pieces. This review highlights the most recent progress on the understanding of corpus callosum formation with a special emphasis on the novel molecular players in the development of axonal projections in the corpus callosum.
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