Autophagy and Inflammatory Response in the Tumor Microenvironment.
Autophagy and Inflammatory Response in the Tumor Microenvironment.
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DOI：
10.3390/ijms18092016
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发表时间：
2017-09-20
影响因子：
5.6
通讯作者：
Kim GD
中科院分区：
文献类型：
--
作者：
Ngabire D;Kim GD
细胞死亡是细胞生命周期的最后命运。到目前为止，参与细胞死亡的不同途径是已知的，主要表现为细胞凋亡、坏死和自噬。自噬是保存最完好的细胞死亡途径之一，其特征是被称为自噬小体的双膜囊消耗后，大部分细胞质成分被消除。然后，形成的自噬小体与含有降解酶的溶酶体融合，并导致自噬小体内容的消化。自噬是由应激相关的诱导物触发的，并且部分依赖于凋亡蛋白。它在癌症中发挥着重要作用，特别是在肿瘤微环境中，它既是肿瘤抑制因子，又是肿瘤促进剂，具有矛盾的功能。在肿瘤微环境中，自噬调节巨噬细胞分化为肿瘤相关巨噬细胞(TAM)和成纤维细胞分化为肿瘤相关成纤维细胞(CAF)。TAMS和CAF广泛存在于肿瘤微环境中，积极参与肿瘤的生长、侵袭和化疗耐药。
Cell death is the last fate of the life cycle of cells. Different pathways involved in cell death are known to date, and are mostly represented by apoptosis, necrosis, and autophagy. Autophagy is one of the most preserved cell death pathways, characterized by the elimination of large parts of cytoplasmic components after being consumed by a double-membraned vesicle called an autophagosome. The formed autophagosome then fuses with a lysosome containing degrading enzymes and leads to the digestion of the autophagosome content. Autophagy is triggered by stress-related inducers, and is partially dependent on apoptotic proteins. It plays a major role in cancer, particularly in the tumor microenvironment where it has a paradoxical function in acting as a tumor suppressor and also as a tumor promoter. In the tumor microenvironment, autophagy regulates the differentiation of macrophages into tumor-associated macrophages (TAMs) and fibroblasts into cancer-associated fibroblasts (CAFs). TAMs and CAFs are abundantly present in the tumor microenvironment, and participate actively in tumor growth, tumor invasiveness, and tumor resistance to chemotherapy.
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AMP激活的蛋白激酶对ULK1（HATG1）的磷酸化将能量传感连接到线粒体。
DOI：
10.1126/science.1196371
发表时间：
2011-01-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Egan DF;Shackelford DB;Mihaylova MM;Gelino S;Kohnz RA;Mair W;Vasquez DS;Joshi A;Gwinn DM;Taylor R;Asara JM;Fitzpatrick J;Dillin A;Viollet B;Kundu M;Hansen M;Shaw RJ
通讯作者：
Shaw RJ
影响因子：
--
作者：
Ávalos Y;Canales J;Bravo-Sagua R;Criollo A;Lavandero S;Quest AF
通讯作者：
Quest AF
DOI：
10.1016/j.biocel.2013.02.007
发表时间：
2013-05-01
影响因子：
4
作者：
Fu, Lei-lei;Cheng, Yan;Liu, Bo
通讯作者：
Liu, Bo
影响因子：
8
作者：
Comito, G.;Giannoni, E.;Chiarugi, P.
通讯作者：
Chiarugi, P.
影响因子：
11.2
作者：
Gewirtz DA
通讯作者：
Gewirtz DA