Greatly increased occurrence of breast cancers in areas of mammographically dense tissue.
Greatly increased occurrence of breast cancers in areas of mammographically dense tissue.
复制标题
乳腺癌乳腺癌的发生大大增加了乳房X线X射线密集组织的区域。
DOI：
10.1186/bcr1260
复制
发表时间：
2005
影响因子：
7.4
通讯作者：
Wu, AH
中科院分区：
文献类型：
--
作者：
Ursin, G;Hovanessian-Larsen, L;Parisky, YR;Pike, MC;Wu, AH
乳腺摄影密度是乳腺癌的一个强有力的独立危险因素。一个关键的未回答的问题是，癌症是否倾向于出现在乳房X线摄影致密组织中（即密度与风险直接相关，还是仅仅是风险的标志）。这个问题不能通过研究浸润性肿瘤来解决，因为它们表现为密度，并且不能确信地与代表纤维和腺组织的密度区分开来。我们通过研究导管原位癌（DCIS）来解决这个问题，如微钙化所示。我们研究了28个乳腺单发DCIS病灶的头尾位和内外斜位钼靶X线片。由两名经验丰富的放射科医生独立判断DCIS是否发生在乳腺X线片上的致密区域，并确定不同区域的乳腺X线片密度。无法确定6个肿瘤的DCIS是否位于致密区。在其余22个病灶中，21个发生在致密组织中（与预期的差异检验，作为包含DCIS的“乳腺摄影象限”的密度百分比; P < 0.0001）。DCIS的优势（28例中的17例）发生在具有最高百分比密度的乳房X线摄影象限中。DCIS绝大多数发生在乳房的乳房X线摄影致密区域，DCIS前的乳房X线摄影显示这种关系不是由DCIS的存在引起的。这有力地表明，包括乳房摄影致密组织的基质组织的某些方面直接影响局部乳腺腺体组织中的致癌过程。
Mammographic density is a strong, independent risk factor for breast cancer. A critical unanswered question is whether cancers tend to arise in mammographically dense tissue (i.e. are densities directly related to risk or are they simply a marker of risk). This question cannot be addressed by studying invasive tumors because they manifest as densities and cannot be confidently differentiated from the densities representing fibrous and glandular tissue. We addressed this question by studying ductal carcinoma in situ (DCIS), as revealed by microcalcifications. We studied the cranio-caudal and the mediolateral-oblique mammograms of 28 breasts with a solitary DCIS lesion. Two experienced radiologists independently judged whether the DCIS occurred in a mammographically dense area, and determined the density of different areas of the mammograms. It was not possible to determine whether the DCIS was or was not in a dense area for six of the tumors. Of the remaining 22 lesions, 21 occurred in dense tissue (test for difference from expected taken as the percentage of density of the 'mammographic quadrant' containing DCIS; P < 0.0001). A preponderance of DCIS (17 out of 28) occurred in the mammographic quadrant with the highest percentage density. DCIS occurs overwhelmingly in the mammographically dense areas of the breast, and pre-DCIS mammograms showed that this relationship was not brought about by the presence of the DCIS. This strongly suggests that some aspect of stromal tissue comprising the mammographically dense tissue directly influences the carcinogenic process in the local breast glandular tissue.
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DOI：
10.1093/jnci/87.21.1622
发表时间：
1995-11-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BYRNE, C;SCHAIRER, C;HAILE, R
通讯作者：
HAILE, R
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ
影响因子：
5
作者：
BRISSON, J;MERLETTI, F;COLE, P
通讯作者：
COLE, P
DOI：
10.1186/bcr622
发表时间：
2003
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Alowami S;Troup S;Al-Haddad S;Kirkpatrick I;Watson PH
通讯作者：
Watson PH
影响因子：
5.5
作者：
OZA, AM;BOYD, NF
通讯作者：
BOYD, NF