Mammographic density is related to stroma and stromal proteoglycan expression.
Mammographic density is related to stroma and stromal proteoglycan expression.
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DOI：
10.1186/bcr622
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Watson PH
中科院分区：
文献类型：
--
作者：
Alowami S;Troup S;Al-Haddad S;Kirkpatrick I;Watson PH
乳腺密度和乳腺组织的某些组织学改变都是乳腺癌的危险因素。然而，这些因素之间的关系仍然不确定。以前的研究集中在上皮变化的组织学上，尽管乳腺基质是体积上的主要组织室。我们以前已经确定lumican和核心蛋白聚糖作为丰富的小亮氨酸丰富的蛋白聚糖在乳腺间质中，乳腺肿瘤发生后表现出改变的表达。在这项研究中，我们检查了乳腺活检的乳腺摄影密度和间质改变之间的关系。我们回顾了年龄在50-69岁的女性的乳房X线照片，这些女性参加了省级乳房X线检查筛查计划，并因随后诊断为良性或浸润前乳腺疾病的异常而接受了切除活检。将总体乳腺摄影密度分为密度类别。审查所有活检组织切片，并选择远离诊断病变的切除边缘的组织块。在用苏木精和伊红染色的切片中评估组织学组成，并通过免疫组织化学评估光蛋白聚糖和核心蛋白聚糖的表达;两者均通过半定量评分进行定量。与乳腺X线摄影低密度相比，对应于高密度区域的组织切片显示导管和小叶单位的密度无显著差异，但显示胶原蛋白密度和纤维化程度显著较高。类似地，光蛋白聚糖和核心蛋白聚糖的表达显著增加。间质成分的改变与乳腺摄影密度增加相关。虽然上皮细胞的变化决定了乳腺癌发展的最终途径，但乳腺摄影密度可能更直接地对应于基质成分的改变。
Mammographic density and certain histological changes in breast tissues are both risk factors for breast cancer. However, the relationship between these factors remains uncertain. Previous studies have focused on the histology of the epithelial changes, even though breast stroma is the major tissue compartment by volume. We have previously identified lumican and decorin as abundant small leucine-rich proteoglycans in breast stroma that show altered expression after breast tumorigenesis. In this study we have examined breast biopsies for a relationship between mammographic density and stromal alterations. We reviewed mammograms from women aged 50–69 years who had enrolled in a provincial mammography screening program and had undergone an excision biopsy for an abnormality that was subsequently diagnosed as benign or pre-invasive breast disease. The overall mammographic density was classified into density categories. All biopsy tissue sections were reviewed and tissue blocks from excision margins distant from the diagnostic lesion were selected. Histological composition was assessed in sections stained with haematoxylin and eosin, and the expression of lumican and decorin was assessed by immunohistochemistry; both were quantified by semi-quantitative scoring. Tissue sections corresponding to regions of high in comparison with low mammographic density showed no significant difference in the density of ductal and lobular units but showed significantly higher collagen density and extent of fibrosis. Similarly, the expression of lumican and decorin was significantly increased. Alteration in stromal composition is correlated with increased mammographic density. Although epithelial changes define the eventual pathway for breast cancer development, mammographic density might correspond more directly to alterations in stromal composition.
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影响因子：
4.8
作者：
Iozzo, RV;Moscatello, DK;Eichstetter, I
通讯作者：
Eichstetter, I
影响因子：
4.7
作者：
Boyd, N F;Martin, L J;Yaffe, M J
通讯作者：
Yaffe, M J
DOI：
10.1093/jnci/87.21.1622
发表时间：
1995-11-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BYRNE, C;SCHAIRER, C;HAILE, R
通讯作者：
HAILE, R
影响因子：
4.1
作者：
dAvis, PY;Frazier, CR;Fedarko, NS
通讯作者：
Fedarko, NS
影响因子：
7.8
作者：
Chakravarti, S;Magnuson, T;Lass, JH;Jepsen, KJ;LaMantia, C;Carroll, H
通讯作者：
Carroll, H