Perinatal Obsessive-Compulsive Disorder: Epidemiology, Phenomenology, Etiology, and Treatment.
Perinatal Obsessive-Compulsive Disorder: Epidemiology, Phenomenology, Etiology, and Treatment.
复制标题
DOI：
10.1007/s11920-022-01333-4
复制
发表时间：
2022-04
影响因子：
6.7
通讯作者：
Osborne, Lauren M.
中科院分区：
文献类型：
--
作者：
Hudepohl, Neha;MacLean, Joanna V.;Osborne, Lauren M.
我们回顾了最近的证据有关的流行病学，病因学和治疗强迫症（OCD）在围产期。我们检查了报告妊娠和产后新发强迫症和加重率的研究;探讨了该疾病的生物学和心理社会风险因素;并回顾了有关治疗的最新证据。所有领域的证据都是有限的，强迫症和阈下强迫症状的发生率在不同的研究中差异很大。围产期的患病率可能高于一般人群。围产期的临床特征比其他时期更有可能对儿童造成伤害，污染和侵略性强迫症以及清洁和检查强迫症尤其常见。目前对生物病因学的研究还很有限，无法确定。观察性和随机对照试验都支持认知行为治疗与暴露和反应预防（CBT与ERP）作为一线治疗，有限的证据也支持使用选择性5-羟色胺再摄取抑制剂（SSRIs）。围产期的治疗考虑必须权衡治疗的风险与未经治疗的疾病的风险。围产期强迫症是常见的，可以损害。与非围产期相比，临床特征有所不同。治疗方法与一般人群中使用的治疗方法没有不同，尽管专门与围产期相关的证据很少。
We review recent evidence concerning the epidemiology, etiology, and treatment of obsessive–compulsive disorder (OCD) in the perinatal period. We examine studies reporting on rates of both new-onset OCD and exacerbation in both pregnancy and postpartum; explore both biological and psychosocial risk factors for the disorder; and review the latest evidence concerning treatment. Evidence is limited in all areas, with rates of both OCD and subthreshold obsessive–compulsive symptoms varying widely across studies. Prevalence is likely higher in the perinatal period than in the general population. Clinical features in the perinatal period are more likely than at other times to concern harm to the child, with contamination and aggressive obsessions and cleaning and checking compulsions especially common. Research into the biological etiology is too limited at this time to be definitive. Both observational and randomized controlled trials support cognitive behavioral therapy with exposure and response prevention (CBT with ERP) as a first-line treatment, with limited evidence also supporting the use of selective serotonin reuptake inhibitors (SSRIs). Treatment considerations in the perinatal period must weigh the risks of treatment vs. the risks of untreated illness. Perinatal OCD is common and can be impairing. Clinical features differ somewhat compared to non-perinatal periods. Treatment does not differ from that used in the general population, though evidence pertaining specifically to the perinatal period is sparse.
登录
查看更多内容
影响因子：
4.5
作者：
Chaudron, Linda H.;Nirodi, Neha
通讯作者：
Nirodi, Neha
影响因子：
2.6
作者：
Dougherty, Darin D.;Jameson, Mariko;Keuthen, Nancy J.
通讯作者：
Keuthen, Nancy J.
影响因子：
4.5
作者：
Abramowitz, Jonathan S.;Meltzer-Brody, Samantha;Pedersen, Cort
通讯作者：
Pedersen, Cort
影响因子：
10.3
作者：
Challacombe, Fiona;Salkovskis, Paul
通讯作者：
Salkovskis, Paul
影响因子：
4.5
作者：
Fairbrother, Nichole;Woody, Sheila R.
通讯作者：
Woody, Sheila R.