Functions of Group 2 Innate Lymphoid Cells in Tumor Microenvironment
Functions of Group 2 Innate Lymphoid Cells in Tumor Microenvironment
复制标题
肿瘤微环境中第2组先天淋巴细胞的功能
DOI：
10.3389/fimmu.2019.01615
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发表时间：
2019-07
影响因子：
7.3
通讯作者：
Qingqing Wang
中科院分区：
文献类型：
--
作者：
Jia Xiong;Haofei Wang;Jia He;Qingqing Wang
先天性淋巴样细胞（inate lymphoid cells，ILC）是一类异质性的淋巴细胞，近年来受到广泛关注。根据转录因子的表达谱和细胞因子产生水平的不同，它们可以分为三个亚群。这些细胞广泛分布于人体器官和组织，尤其是粘膜组织。ILC参与多种生理和病理过程，包括炎症、蠕虫排出、自身免疫性疾病和肿瘤进展，其中许多在最近的研究中已经被研究和阐明。在肿瘤微环境中，第2组先天性淋巴样细胞（ILC2）已被证明能够通过产生不同的细胞因子、募集不同类型的免疫细胞、表达免疫抑制分子以及通过调节某些炎症因子的表达来促进或抑制肿瘤进展。本文就ILC2在肿瘤微环境中的免疫调节功能的研究进展进行综述，并对今后的研究提出展望。
Innate lymphoid cells (ILCs), defined as a heterogeneous population of lymphocytes, have received much attention over recent years. They can be categorized into three subsets according to the expression profiles of transcription factors and differing levels of cytokine production. These cells are widely distributed in human organs and tissues, especially in mucosal tissue. The ILCs are involved in various physiological and pathological processes, including inflammation, worm expulsion, autoimmune disease and tumor progression, many of which have been investigated and clarified in recent studies. In the tumor microenvironment, group 2 innate lymphoid cells (ILC2s) have been proved to be able to either promote or inhibit tumor progression by producing different cytokines, recruiting diverse types of immune cells, expressing immunosuppressive molecules and by regulating the expression of certain inflammatory factors. This review summarizes recent research progress on the immunomodulatory functions of ILC2s in the tumor microenvironment and puts forward some perspectives for future study.
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影响因子：
16.6
作者：
Trabanelli S;Chevalier MF;Martinez-Usatorre A;Gomez-Cadena A;Salomé B;Lecciso M;Salvestrini V;Verdeil G;Racle J;Papayannidis C;Morita H;Pizzitola I;Grandclément C;Bohner P;Bruni E;Girotra M;Pallavi R;Falvo P;Leibundgut EO;Baerlocher GM;Carlo-Stella C;Taurino D;Santoro A;Spinelli O;Rambaldi A;Giarin E;Basso G;Tresoldi C;Ciceri F;Gfeller D;Akdis CA;Mazzarella L;Minucci S;Pelicci PG;Marcenaro E;McKenzie ANJ;Vanhecke D;Coukos G;Mavilio D;Curti A;Derré L;Jandus C
通讯作者：
Jandus C
DOI：
10.1126/science.aad9903
发表时间：
2016-03-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Duffin R;O'Connor RA;Crittenden S;Forster T;Yu C;Zheng X;Smyth D;Robb CT;Rossi F;Skouras C;Tang S;Richards J;Pellicoro A;Weller RB;Breyer RM;Mole DJ;Iredale JP;Anderton SM;Narumiya S;Maizels RM;Ghazal P;Howie SE;Rossi AG;Yao C
通讯作者：
Yao C
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
影响因子：
32.4
作者：
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通讯作者：
Avram D