Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets.
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets.
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先天淋巴样细胞（ILCs）的多样性正在迅速扩大。ILC1、ILC2和ILC3是ILC的三种类型，其中ILC1和ILC3包括几个子集。一些亚群的分类尚不清楚，NK细胞和ILC1是否是不同的细胞类型仍然存在争议。为了解决这些问题，我们分析了小鼠小肠、脾脏和肝脏中ILCs和NK细胞的基因表达，作为免疫基因组计划的一部分。结果确定了一些ILC的独特基因表达模式以及ILC1和NK细胞之间的重叠模式，而少数ILC亚群仍然无法区分。确定了小肠ILC和核心ILC签名共享的转录程序。揭示和讨论了新的ILC功能和发育途径的转录本。
The diversity of innate lymphoid cells (ILCs) is rapidly expanding. Three ILC classes have emerged, ILC1, ILC2, and ILC3, with ILC1 and ILC3 including several subsets. The classification of some subsets is unclear and it remains controversial whether NK cells and ILC1 are distinct cell types. To address these issues, we analyzed ILCs and NK cells gene expression within mouse small intestine, spleen, and liver, as part of the Immunological Genome Project. Results identify unique gene-expression patterns for some ILCs and overlapping patterns between ILC1 and NK cells, whereas few ILC subsets remain indistinguishable. A transcriptional program shared by small intestine ILCs and a core ILC signature is identified. Transcripts that suggest novel ILC functions and developmental paths are revealed and discussed.
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DOI：
10.1084/jem.20092176
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kamizono S;Duncan GS;Seidel MG;Morimoto A;Hamada K;Grosveld G;Akashi K;Lind EF;Haight JP;Ohashi PS;Look AT;Mak TW
通讯作者：
Mak TW
影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
DOI：
10.1084/jem.20121964
发表时间：
2013-03-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Molofsky AB;Nussbaum JC;Liang HE;Van Dyken SJ;Cheng LE;Mohapatra A;Chawla A;Locksley RM
通讯作者：
Locksley RM
影响因子：
30.5
作者：
Lee, Jacob S.;Cella, Marina;McDonald, Keely G.;Garlanda, Cecilia;Kennedy, Gregory D.;Nukaya, Manabu;Mantovani, Alberto;Kopan, Raphael;Bradfield, Christopher A.;Newberry, Rodney D.;Colonna, Marco
通讯作者：
Colonna, Marco