Semisynthesis and antifeedant activity of new derivatives of a dihydro-β-agarofuran from Parnassia wightiana.
Semisynthesis and antifeedant activity of new derivatives of a dihydro-β-agarofuran from Parnassia wightiana.
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来自 Parnassia wightiana 的二氢-β-沉香呋喃新衍生物的半合成和拒食活性
DOI：
10.3390/ijms141019484
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发表时间：
2013-09-26
影响因子：
5.6
通讯作者：
Gao JM
中科院分区：
文献类型：
--
作者：
Tang JJ;Zhang FY;Wang DM;Tian JM;Dong S;Gao JM
以从梅花草中得到的具有C-2酮的二氢-β-琼呋喃类化合物1为原料，分别经过酰化、氧化、还原、酯化和胺化反应，半合成了五个新衍生物（2-6）。2-6的结构通过1D-和2D-NMR和HR-ESI-MS光谱确认。此外，还测定了化合物（1-6）对粘虫（Mythimna separata）3龄幼虫的拒食活性。化合物2和4的拒食作用大于母体化合物1，而其他化合物对三龄M表现出低的或没有拒食作用。在实验室生物测定中分离的幼虫。因此，我们的研究结果表明，酰化和还原衍生物在C-8和C-2，分别为1可能会提高拒食效果。这些初步信息将有助于设计新的昆虫防治剂。分离物和其他重要害虫。
Five new derivatives (2–6) were semi-synthesized using compound 1, a dihydro-β-agarofuran sesquiterpene with C-2 ketone obtained from Parnassia wightiana, as the starting material by acylation, oxidation, reduction, esterification, and amination, respectively. Structures of 2–6 were confirmed by 1D- and 2D-NMR and HR-ESI-MS spectra. In addition, antifeedant activities of these compounds (1–6) were tested against the 3rd-instar larvae of Mythimna separata. Antifeedant effects of compounds 2 and 4 were greater than the parent compound 1 whereas other compounds exhibited low to no feeding deterrent effects against third instar M. separata larvae in lab bioassays. Therefore, our results suggest that acylated and reduced derivatives at C-8 and C-2, respectively, of 1 may improve the antifeeding effect. This preliminary information will be useful in designing new insect control agents against M. separata and other important pests.
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影响因子：
1
作者：
JOHNSON, LA;SOLTIS, DE
通讯作者：
SOLTIS, DE
影响因子：
6.1
作者：
Akhtar, Yasmin;Isman, Murray B.;Plettner, Erika
通讯作者：
Plettner, Erika
DOI：
10.1016/j.bbrc.2005.02.009
发表时间：
2005-04-08
影响因子：
3.1
作者：
Cortés-Selva, F;Muñoz-Martínez, F;Castanys, S
通讯作者：
Castanys, S
影响因子：
4.9
作者：
Iwai, Takayoshi;Seo, Shigemi;Ohashi, Yuko
通讯作者：
Ohashi, Yuko
影响因子：
1.8
作者：
Duan, HQ;Takaishi, Y;Lee, KH
通讯作者：
Lee, KH