Immunoglobulin and T cell receptor gene configuration in acute lymphoblastic leukemia of infancy.
Immunoglobulin and T cell receptor gene configuration in acute lymphoblastic leukemia of infancy.
复制标题
婴儿急性淋巴细胞白血病的免疫球蛋白和 T 细胞受体基因配置。
DOI：
10.1182/blood.v70.2.536.536
复制
发表时间：
1987
期刊：
影响因子：
20.3
通讯作者：
I. Kirsch
中科院分区：
文献类型：
--
作者：
C. Felix;G. Reaman;S. Korsmeyer;G. Hollis;P. Dinndorf;J. Wright;I. Kirsch
我们检测了一系列年龄小于1岁的急性淋巴细胞白血病（ALL）婴儿的白血病细胞中免疫球蛋白（IG）重链、K轻链和T细胞受体（TCR）γ和β基因构型。这11例病例中的每一个都证明了与B细胞前体表型相关的白血病细胞表面抗原。在11例中，4例淋巴母细胞保留了IG和TCR基因座的种系构型，而7例发生了IG重链基因重排。这7个中的2个显示轻链基因重排。TCB β链重排仅发生在11例患者的肿瘤中的1例中。未发现TCR γ链重排。这些结果与儿童B细胞前体ALL的早期研究相反，在早期研究中，IG重链基因重排在每种情况下都很明显，大约40%的儿童也显示出IG轻链重排。此外，45%的儿童B细胞前体ALL病例发生了γ TCR基因重排，20%发生了β TCR基因重排。这些数据表明，婴儿期ALL代表了比儿童B细胞前体ALL更早的B细胞发育阶段。婴儿年龄组的ALL与所有ALL患者的最差预后相关。这项研究表明，婴儿的疾病不仅在临床上不同，而且在分子遗传水平上也不同于儿童的疾病。
We examined immunoglobulin (Ig) heavy chain, K light chain, and T cell receptor (TCR) gamma and beta gene configuration in the leukemic cells from a series of infants aged less than 1 year with acute lymphoblastic leukemia (ALL). Each of these 11 cases demonstrated leukemic cell surface antigens that have been correlated with a B cell precursor phenotype. Of the 11, lymphoblasts of 4 retained the germline configuration of both Ig and TCR loci, whereas 7 had rearranged the Ig heavy chain gene. Two of these seven showed light chain gene rearrangement. TCB beta chain rearrangement had occurred in only one of the 11 patients' tumors. No TCR gamma chain rearrangements were identified. These results are in contrast to earlier studies of B cell precursor ALL in children in which Ig heavy chain gene rearrangements were evident in every case and approximately 40% showed Ig light chain rearrangement as well. In addition, 45% of cases of B cell precursor ALL of children had rearranged their gamma TCR genes, and 20% had rearranged beta. These data suggest that ALL in infancy represents an earlier stage of B cell development than is found in B cell precursor ALL of children. ALL in the infant age group has been associated with the worst prognosis of all patients with ALL. This study suggests that the disease in infants differs not only clinically, but also at the molecular genetic level, from the disease in children.
登录
查看更多内容
非T细胞急性淋巴细胞白血病的B细胞起源。
DOI：
10.1172/jci111428
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Nadler,LM;Korsmeyer,SJ;Anderson,KC;Boyd,AW;Slaughenhoupt,B;Park,E;Jensen,J;Coral,F;Mayer,RJ;Sallan,SE
通讯作者：
Sallan,SE
影响因子：
158.5
作者：
CLAVELL, LA;GELBER, RD;SALLAN, SE
通讯作者：
SALLAN, SE
影响因子：
20.3
作者：
ANDERSON, KC;BATES, MP;NADLER, LM
通讯作者：
NADLER, LM
儿童 T 细胞淋巴恶性肿瘤表面抗原的单克隆抗体表征。
影响因子：
20.3
作者：
Roper,M;Crist,WM;Metzgar,R;Ragab,AH;Smith,S;Starling,K;Pullen,J;Leventhal,B;Bartolucci,AA;Cooper,MD
通讯作者：
Cooper,MD
人类 T 细胞伽马链基因：组织、多样性和重排。
DOI：
10.1126/science.3079918
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Quertermous,T;Murre,C;Dialynas,D;Duby,AD;Strominger,JL;Waldman,TA;Seidman,JG
通讯作者：
Seidman,JG