Novel diamond shuttle to deliver flexible bioelectronics with reduced tissue compression
Novel diamond shuttle to deliver flexible bioelectronics with reduced tissue compression
复制标题
新型金刚石梭可提供灵活的生物电子学并减少组织压缩
DOI：
10.1101/435800
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
J. Seymour
中科院分区：
文献类型：
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作者：
Kyounghwan Na;Zachariah J. Sperry;Jiaao Lu;M. Vöröslakos;Saman Parizi;T. Bruns;E. Yoon;J. Seymour
通过中枢和外周神经系统最坚硬的膜传递柔性生物传感器的能力是神经科学和神经工程中的一个重要挑战。通过硬脑膜和厚神经外膜植入生物电子设备，理想情况下会产生最小的压迫和急性损伤，因为它们到达了感兴趣的神经元。我们证明，三维钻石航天飞机可以很容易地制作成垂直支撑物，通过硬脑膜和厚神经外膜在体内输送超顺应性聚合物微电极(4.5MWM厚)。钻石穿梭的横截面积比同等硬度的硅穿梭小54%，我们模拟的结果是血管损伤减少了37%。我们还发现，无论插入速度如何，航天飞机的高频振荡(200赫兹)显著降低了组织压缩，而低速也独立地减少了组织压缩。插入和记录性能在大鼠和猫科动物模型中得到验证，但这些工具的巨大设计空间适合在各种动物模型和神经系统靶标中进行研究。
The ability to deliver flexible biosensors through the toughest membranes of the central and peripheral nervous system is an important challenge in neuroscience and neural engineering. Bioelectronic devices implanted through dura mater and thick epineurium would ideally create minimal compression and acute damage as they reach the neurons of interest. We demonstrate that a three-dimensional diamond shuttle can be easily made with a vertical support to deliver ultra-compliant polymer microelectrodes (4.5 μm thick) in-vivo through dura mater and thick epineurium. The diamond shuttle has 54% less cross-sectional area than an equivalently stiff silicon shuttle, which we simulated will result in a 37% reduction in blood vessel damage. We also discovered that higher frequency oscillation of the shuttle (200 Hz) significantly reduced tissue compression regardless of the insertion speed, while slow speeds also independently reduced tissue compression. Insertion and recording performance are demonstrated in rat and feline models, but the large design space of these tools are suitable for research in a variety of animal models and nervous system targets.
DOI：
10.1007/978-1-60761-938-3_6
发表时间：
2011-01-01
期刊：
BLOOD-BRAIN AND OTHER NEURAL BARRIERS: REVIEWS AND PROTOCOLS
影响因子：
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作者：
Weerasuriya, Ananda;Mizisin, Andrew P.
通讯作者：
Mizisin, Andrew P.
影响因子：
14
作者：
Buehler, C.;Kleber, C.;Asplund, M.
通讯作者：
Asplund, M.