Overexpression of runt-related transcription factor-2 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer.
Overexpression of runt-related transcription factor-2 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer.
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DOI：
10.1155/2012/456534
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发表时间：
2012
影响因子：
--
通讯作者：
Zhao W
中科院分区：
文献类型：
--
作者：
Li W;Xu S;Lin S;Zhao W
瞄准目的探讨Runt相关转录因子（RUNX）-2在上皮性卵巢癌（EOC）中的表达及临床意义。 方法.采用免疫组化法检测116例EOC中RUNX 2蛋白的表达及其亚细胞定位。 结果RUNX 2蛋白主要表达于上皮性卵巢癌组织的细胞核。RUNX 2在EOC组织中的表达水平显著高于正常卵巢组织（P < 0.001）。此外，肿瘤细胞中RUNX 2的核标记指数（LI）与EOC组织的晚期临床分期显著相关（P = 0.001）。此外，高RUNX 2 LI的EOC患者的总体生存期（P < 0.001）和无进展生存期（P = 0.002）显著短于低RUNX 2 LI的患者。特别是亚组分析显示，RUNX 2高表达组中临床分期高（III~IV期）的EOC患者的临床预后明显差于RUNX 2低表达组，而临床分期低（I~II期）的EOC患者的预后在RUNX 2高表达组和低表达组之间无明显差异。 结论.我们的数据首次表明RUNX 2过表达与EOC患者的晚期肿瘤进展和不良临床结局相关。RUNX 2可能是EOC的一个新的预后指标。
Aim. To investigate clinical significance of runt-related transcription factor (RUNX)-2 in epithelial ovarian cancer (EOC). Methods. RUNX2 protein expression and its subcellular localization were detected by immunohistochemistry in 116 patients with EOC. Results. RUNX2 protein was predominantly expressed in cell nucleus of EOC tissues. The expression level of RUNX2 in EOC tissues was significantly higher than that in normal ovarian tissues (P < 0.001). In addition, the nuclear labeling index (LI) of RUNX2 in tumor cells was significantly associated with the advanced clinical stage of EOC tissues (P = 0.001). Moreover, EOC patients with high RUNX2 LI had significantly shorter overall (P < 0.001) and progression-free (P = 0.002) survival than those with low RUNX2 LI. Especially, subgroup analysis revealed that EOC patients with high clinical stages (III~IV) in high RUNX2 expression group demonstrated a significantly worse clinical outcome than those in low RUNX2 expression group, but patients with low clinical stages (I~II) had no significantly different prognosis between high and low RUNX2 expression groups. Conclusions. Our data suggest for the first time that RUNX2 overexpression is associated with advanced tumor progression and poor clinical outcome of EOC patients. RUNX2 might be a novel prognostic marker of EOC.
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