Mechanisms involved in controlling RNA virus-induced intestinal inflammation.
Mechanisms involved in controlling RNA virus-induced intestinal inflammation.
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DOI：
10.1007/s00018-022-04332-z
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发表时间：
2022-05-23
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影响因子：
--
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中科院分区：
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胃肠炎是胃和肠内壁的炎症，在世界范围内引起显著的发病率和死亡率。许多病毒，特别是RNA病毒是肠炎最常见的原因。天然免疫是宿主抵抗肠道RNA病毒和病毒诱导的肠道炎症的第一道防线。肠道中抵抗肠道RNA病毒的第一层防御是肠上皮细胞（IEC）、树突状细胞和肠上皮下的巨噬细胞。这些先天性免疫细胞表达病原体识别受体（PRR），用于通过感测病毒病原体相关分子模式（PAMP）来识别肠道RNA病毒。作为这种识别的结果，I型干扰素（IFN）、III型IFN和炎性小体活化发生，其协同作用以清除感染并减少病毒诱导的肠道炎症。本文就肠道RNA病毒引起肠道炎症的机制作一综述。我们将提供一个概述肠道RNA病毒，其RNA传感机制的主机PRR，和信号转导途径引发的主机PRR，形成肠道免疫反应，以维持肠道内稳态。
Gastroenteritis is inflammation of the lining of stomach and intestines and causes significant morbidity and mortality worldwide. Many viruses, especially RNA viruses are the most common cause of enteritis. Innate immunity is the first line of host defense against enteric RNA viruses and virus-induced intestinal inflammation. The first layer of defense against enteric RNA viruses in the intestinal tract is intestinal epithelial cells (IECs), dendritic cells and macrophages under the intestinal epithelium. These innate immune cells express pathogen-recognition receptors (PRRs) for recognizing enteric RNA viruses through sensing viral pathogen-associated molecular patterns (PAMPs). As a result of this recognition type I interferon (IFN), type III IFN and inflammasome activation occurs, which function cooperatively to clear infection and reduce viral-induced intestinal inflammation. In this review, we summarize recent findings about mechanisms involved in enteric RNA virus-induced intestinal inflammation. We will provide an overview of the enteric RNA viruses, their RNA sensing mechanisms by host PRRs, and signaling pathways triggered by host PRRs, which shape the intestinal immune response to maintain intestinal homeostasis.
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影响因子：
8.8
作者：
Feng Q;Hato SV;Langereis MA;Zoll J;Virgen-Slane R;Peisley A;Hur S;Semler BL;van Rij RP;van Kuppeveld FJ
通讯作者：
van Kuppeveld FJ
DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
30.5
作者：
Broggi A;Tan Y;Granucci F;Zanoni I
通讯作者：
Zanoni I
影响因子：
64.8
作者：
Ding, Jingjin;Wang, Kun;Shao, Feng
通讯作者：
Shao, Feng