The beta2-adrenergic receptor on T and B lymphocytes: do we understand it yet?
The beta2-adrenergic receptor on T and B lymphocytes: do we understand it yet?
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DOI：
10.1016/j.bbi.2011.08.001
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发表时间：
2012-02
影响因子：
15.1
通讯作者：
Sanders, Virginia M.
中科院分区：
文献类型：
--
作者：
Sanders, Virginia M.
关键词：
β_2肾上腺素能受体（β_2AR）在调节T、B淋巴细胞功能水平中的作用已被研究了半个多世纪。在此期间，我们了解到T和B淋巴细胞几乎只表达β 2 AR，并且由于组蛋白和DNA甲基化的表观遗传调节，特定淋巴细胞亚群的表达水平不同。我们还了解到，通过去甲肾上腺素或选择性药理学配体与淋巴细胞上的β2AR结合，可以不同地调节淋巴细胞活性水平，这取决于与细胞活化和分化状态相关的受体结合时间、活化的分子信号传导途径和细胞因子微环境。现在的挑战是确定我们是否足够了解这种受体在淋巴细胞上的功能，以预测这种调节与整体免疫稳态和人类疾病的发展/进展的相关性。
The role played by the beta2-adrenergic receptor (β2AR) in regulating the level of T and B lymphocyte function has been studied for over half a century. During this time, we have learned that T and B lymphocytes express almost exclusively the β2AR, and that the level of expression on a specific lymphocyte subset differs due to epigenetic regulation by histone and DNA methylation. We have also learned that engagement of the β2AR on lymphocytes, by either norepinephrine or a selective pharmacologic ligand, regulates the level of lymphocyte activity differentially, depending on the time of receptor engagement in relation to the activation and differentiation state of the cell, the molecular signaling pathway activated, and the cytokine microenvironment. The challenge now is to determine if we understand enough about how this receptor functions on lymphocytes to predict the relevance of such regulation to overall immune homeostasis and the development/progression of human disease.
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影响因子：
15.1
作者：
Nance, Dwight M.;Sanders, Virginia M.
通讯作者：
Sanders, Virginia M.
影响因子：
15.1
作者：
Serpe, CJ;Coers, S;Jones, KJ
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Jones, KJ
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5.3
作者：
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Sanders, Virginia M.
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15.1
作者：
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影响因子：
4.4
作者：
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通讯作者：
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