Sulphur metabolism in colon cancer tissues: a case report and literature review.
Sulphur metabolism in colon cancer tissues: a case report and literature review.
复制标题
结肠癌组织中的硫代谢：病例报告和文献综述。
DOI：
10.1177/03000605211059936
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Endo I
中科院分区：
文献类型：
--
作者：
Fukuoka H;Andou T;Moriya T;Narita K;Kasahara K;Miura D;Sekiguchi Y;Suzuki S;Nakagawa K;Ozawa M;Ishibe A;Endo I
由于肠道气体中存在甲硫醇以及与硫代谢微生物区系有关的长期饮食摄入量等因素，含硫化合物与结直肠癌有关。因此，目前的病例报告假设，结直肠癌中活跃的硫代谢导致肠道中硫化合物的形成，从而检查了结肠癌组织中可能与硫呼吸有关的硫代谢产物。患者为73岁女性，因升结肠癌接受了腹腔镜右半结肠切除术。术中采集结肠癌组织和正常肠粘膜标本。在优化样品浓度以进行均质(前处理)后，样品用含羟基苯衍生物稳定，相关代谢物用液相色谱-串联质谱仪进行定量。结果显示，结肠癌组织中的半胱氨酸过硫化物和三硫半胱氨酸水平高于正常粘膜组织。因此，结肠癌组织中的硫代谢，可能是硫的呼吸作用被增强。
Sulphur-containing compounds have been linked to colorectal cancer by factors such as the presence of methyl mercaptan in intestinal gas and long-term dietary intake associated with sulphur-metabolizing microbiota. Therefore, this current case report hypothesized that active sulphur metabolism in colorectal cancer results in the formation of sulphur compounds in the intestine and, thus, examined sulphur metabolites possibly associated with sulphur respiration in colon cancer tissues. The patient was a 73-year-old female that underwent laparoscopic right hemicolectomy for ascending colon cancer. During the surgery, colon cancer tissues and normal intestinal mucosa samples were collected. After optimizing the sample concentrations for homogenization (pre-treatment), the samples were stabilized using a hydroxyphenyl-containing derivative and the relevant metabolites were quantified using liquid chromatography with tandem mass spectrometry. The results showed that cysteine persulfide and cysteine trisulfide levels were higher in colon cancer tissues than in normal mucosal tissues. Thus, sulphur metabolism, possibly sulphur respiration, is enhanced in colon cancer tissues.
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影响因子：
30.3
作者：
Kelly CJ;Zheng L;Campbell EL;Saeedi B;Scholz CC;Bayless AJ;Wilson KE;Glover LE;Kominsky DJ;Magnuson A;Weir TL;Ehrentraut SF;Pickel C;Kuhn KA;Lanis JM;Nguyen V;Taylor CT;Colgan SP
通讯作者：
Colgan SP
影响因子：
5.5
作者：
Sawa T;Motohashi H;Ihara H;Akaike T
通讯作者：
Akaike T
影响因子：
2.7
作者：
Ishibe, Atsushi;Ota, Mitsuyoshi;Endo, Itaru
通讯作者：
Endo, Itaru
影响因子：
3.7
作者：
Stephen AS;Millhouse E;Sherry L;Aduse-Opoku J;Culshaw S;Ramage G;Bradshaw DJ;Burnett GR;Allaker RP
通讯作者：
Allaker RP
影响因子：
3.3
作者：
Nakano, Y;Yoshimura, M;Koga, T
通讯作者：
Koga, T