Laboratory-induced cue reactivity among individuals with prescription opioid dependence.
Laboratory-induced cue reactivity among individuals with prescription opioid dependence.
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DOI：
10.1016/j.addbeh.2014.04.007
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发表时间：
2014-08
影响因子：
4.4
通讯作者：
Brady, Kathleen T.
中科院分区：
文献类型：
--
作者：
Back, Sudie E.;Gros, Daniel F.;McCauley, Jenna L.;Flanagan, Julianne C.;Cox, Elizabeth;Barth, Kelly S.;Brady, Kathleen T.
处方阿片类药物依赖是一个严重的健康问题。虽然对药物线索反应性范式的研究促进了对多种物质（如可卡因、酒精、尼古丁）复发风险因素的理解，但尚未开发出PO特异性药物线索范式。目前的研究填补了文献中的这一空白，并评估了新开发的PO药物线索范式在PO依赖参与者（n = 20）中引起主观、生理和神经内分泌变化的能力，与对照组（n = 17）相比。药物线索范式包括一个归纳脚本，查看和处理随身物品（例如，一瓶奥施康定药片，碾碎机），观看一个视频，描述人们使用POs以及与POs相关的地方（例如，药店）。与假设一致，PO组在渴望、抵抗PO的困难、压力和愤怒的主观评分上表现出显著的事前和事后的增加。对照组在任何主观测量上都没有表现出显著的变化。鉴于药物线索刺激的唤醒性质，PO组和对照组的生理反应（如血压、皮肤电导）在提示前后都有显著的增加。PO组，而不是对照组，在提示前和提示后心率和唾液皮质醇水平显著增加。POs药物提示范式的开发和验证可能有助于为POs依赖患者的未来研究和治疗开发工作提供信息。
Prescription opioid (PO) dependence is a critical health problem. Although examination of drug cue reactivity paradigms has advanced the understanding of risk factors for relapse for a variety of substances (e.g., cocaine, alcohol, nicotine), no PO specific drug cue paradigm has been developed. The current study addressed this gap in the literature and evaluated the ability of a newly developed PO drug cue paradigm to elicit subjective, physiological, and neuroendocrine changes among PO-dependent participants (n = 20) as compared to controls (n = 17). The drug cue paradigm included an induction script, viewing and handling paraphernalia (e.g., bottle of oxycontin pills, pill crusher) and watching a video depicting people using POs as well as places related to POs (e.g., pharmacies). Consistent with hypotheses, the PO group demonstrated significant pre- to post-cue increases on subjective ratings of craving, difficulty resisting POs, stress, and anger. The control group did not demonstrate significant changes on any of the subjective measures. Both the PO group and the control group evidenced significant pre- to post-cue increases in physiological responses (e.g., blood pressure, skin conductance), as expected given the arousing nature of the drug cue stimuli. The PO group, but not the control group, evidenced a significant pre- to post-cue increase in heart rate and salivary cortisol levels. The development and validation of a drug cue paradigm for POs may help inform future research and treatment development efforts for patients with PO dependence.
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影响因子：
6
作者：
Drummond, DC
通讯作者：
Drummond, DC
影响因子：
--
作者：
Carroll, KM;Ball, SA;Rounsaville, BJ
通讯作者：
Rounsaville, BJ
影响因子：
4.2
作者：
Back, Sudie E.;Hartwell, Karen;Braly, Kathleen T.
通讯作者：
Braly, Kathleen T.
影响因子：
6
作者：
Carter, BL;Tiffany, ST
通讯作者：
Tiffany, ST
影响因子：
2.3
作者：
Conklin, CA
通讯作者：
Conklin, CA