Variants in MTNR1B influence fasting glucose levels.
Variants in MTNR1B influence fasting glucose levels.
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DOI：
10.1038/ng.290
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发表时间：
2009-01
期刊：
影响因子：
30.8
通讯作者：
Abecasis GR
中科院分区：
文献类型：
--
作者：
Prokopenko I;Langenberg C;Florez JC;Saxena R;Soranzo N;Thorleifsson G;Loos RJ;Manning AK;Jackson AU;Aulchenko Y;Potter SC;Erdos MR;Sanna S;Hottenga JJ;Wheeler E;Kaakinen M;Lyssenko V;Chen WM;Ahmadi K;Beckmann JS;Bergman RN;Bochud M;Bonnycastle LL;Buchanan TA;Cao A;Cervino A;Coin L;Collins FS;Crisponi L;de Geus EJ;Dehghan A;Deloukas P;Doney AS;Elliott P;Freimer N;Gateva V;Herder C;Hofman A;Hughes TE;Hunt S;Illig T;Inouye M;Isomaa B;Johnson T;Kong A;Krestyaninova M;Kuusisto J;Laakso M;Lim N;Lindblad U;Lindgren CM;McCann OT;Mohlke KL;Morris AD;Naitza S;Orrù M;Palmer CN;Pouta A;Randall J;Rathmann W;Saramies J;Scheet P;Scott LJ;Scuteri A;Sharp S;Sijbrands E;Smit JH;Song K;Steinthorsdottir V;Stringham HM;Tuomi T;Tuomilehto J;Uitterlinden AG;Voight BF;Waterworth D;Wichmann HE;Willemsen G;Witteman JC;Yuan X;Zhao JH;Zeggini E;Schlessinger D;Sandhu M;Boomsma DI;Uda M;Spector TD;Penninx BW;Altshuler D;Vollenweider P;Jarvelin MR;Lakatta E;Waeber G;Fox CS;Peltonen L;Groop LC;Mooser V;Cupples LA;Thorsteinsdottir U;Boehnke M;Barroso I;Van Duijn C;Dupuis J;Watanabe RM;Stefansson K;McCarthy MI;Wareham NJ;Meigs JB;Abecasis GR
为了确定与空腹血糖浓度相关的新的遗传基因座，我们检查了10个全基因组关联扫描中的主要关联信号，共涉及36，610名欧洲血统的个体。在所有10项研究中，编码褪黑激素受体1B（MTNR 1B）的基因变异与空腹血糖一致相关。在rs 10830963处观察到最强的信号，其中每个G等位基因（HapMap CEU中的频率为0.30）与空腹血糖水平增加0.07（95%CI 0.06-0.08）mmol/L（P=3.2×10−50）和稳态模型评估（HOMA-B，P=1.1×10−15）测量的β细胞功能降低相关。在对13项病例对照研究（共18，236例病例和64，453例对照）的荟萃分析中，相同的等位基因与2型糖尿病风险增加相关（比值比= 1.09（1.05-1.12），每个G等位基因P=3.3×10−7）。我们的分析也证实了空腹血糖与G6 PC 2（rs 560887，P=1.1×10−57）和GCK（rs 4607517，P=1.0×10−25）位点变异的相关性。
To identify novel genetic loci associated with fasting glucose concentrations, we examined the leading association signals in 10 genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding the melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G-allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95%CI 0.06–0.08) mmol/L in fasting glucose levels (P=3.2×10−50) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P=1.1×10−15). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05–1.12), per G allele P=3.3×10−7) in a meta-analysis of thirteen case-control studies totalling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P=1.1×10−57) and GCK (rs4607517, P=1.0×10−25) loci.
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影响因子：
9.8
作者：
Schadt EE;Molony C;Chudin E;Hao K;Yang X;Lum PY;Kasarskis A;Zhang B;Wang S;Suver C;Zhu J;Millstein J;Sieberts S;Lamb J;GuhaThakurta D;Derry J;Storey JD;Avila-Campillo I;Kruger MJ;Johnson JM;Rohl CA;van Nas A;Mehrabian M;Drake TA;Lusis AJ;Smith RC;Guengerich FP;Strom SC;Schuetz E;Rushmore TH;Ulrich R
通讯作者：
Ulrich R
DOI：
10.1152/ajpendo.1996.271.2.e246
发表时间：
1996-08-01
影响因子：
5.1
作者：
Boden, G;Ruiz, J;Chen, XH
通讯作者：
Chen, XH
影响因子：
10.3
作者：
Peschke, Elmar;Stumpf, Ina;Muehlbauer, Eckhard
通讯作者：
Muehlbauer, Eckhard
影响因子：
2.2
作者：
Herder, C.;Rathmann, W.;Illig, T.
通讯作者：
Illig, T.
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC