High triglyceride-glucose index in young adulthood is associated with incident cardiovascular disease and mortality in later life: insight from the CARDIA study.
High triglyceride-glucose index in young adulthood is associated with incident cardiovascular disease and mortality in later life: insight from the CARDIA study.
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成年早期的高甘油三酯-葡萄糖指数与晚年心血管疾病发生率和死亡率相关：来自 CARDIA 研究的见解
DOI：
10.1186/s12933-022-01593-7
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发表时间：
2022-08-12
影响因子：
9.3
通讯作者：
Liao, Xinxue
中科院分区：
文献类型：
--
作者：
Xu, Xinghao;Huang, Rihua;Lin, Yifen;Guo, Yue;Xiong, Zhenyu;Zhong, Xiangbin;Ye, Xiaomin;Li, Miaohong;Zhuang, Xiaodong;Liao, Xinxue
研究背景本研究旨在调查青年时期的甘油三酯-葡萄糖(TYG)指数与心血管疾病(CVD)发生率和死亡率之间的关系。TYG指数计算为ln(空腹Tg[mg/dl] × 空腹血糖[mg/dl]/2)，并采用潜在班级生长混合模型识别TYG指数轨迹。我们使用COX比例风险回归分析评估了TYG指数的基线和轨迹与心血管事件和全因死亡率之间的关系。结果在4754名参与者中(平均年龄24.72岁，男性45.8%，黑人51.2%)，在中位数25年的随访期内，共发生158起心血管事件，246例全因死亡。在调整了多个混杂变量后，TYG指数每增加一个单位，心血管风险增加96%(危险比[HR]1.96，95%可信区间[CI]1.44-2.66)，全因死亡风险增加85%(HR 1.85，95%CI 1.45-2.36)。TYG指数在随访期间有三种不同的轨迹：低(44.0%)、中(45.5%)和高(10.5%)。与低TYG指数轨迹组相比，高TYG指数轨迹组发生心血管事件的风险(HR 2.35，95%CI 1.34~4.12)和全因死亡率(HR 3.04，95%CI 1.83~5.07)更高。将基线TYG指数添加到心血管疾病合并队列方程中，改善了C统计量(P <； 0.001)、综合判别度改善值(P <； 0.001)和无分类净重分类改善值(P = 0.003)。结论青年时期基线TYG指数水平和TYG指数长期轨迹越高，发生心血管事件的风险和晚年全因死亡率的风险越高。
BackgroundThis study aimed to investigate the associations between the triglyceride-glucose (TyG) index in young adulthood with incident cardiovascular disease (CVD) and mortality.MethodsWe included 4,754 participants from the Coronary Artery Risk Development in Young Adults study at baseline. The TyG index was calculated as ln (fasting TG [mg/dl] × fasting glucose [mg/dl]/2), and the TyG index trajectories were identified by using the latent class growth mixture model. We evaluated the association between the baseline and trajectories of the TyG index with incident CVD events and all-cause mortality using Cox proportional hazards regression analysis. The added value of the TyG index included in pooled cohort equations for CVD prediction was also analyzed.ResultsAmong 4754 participants (mean age 24.72 years, 45.8% male, 51.2% black), there were 158 incident CVD events and 246 all-cause mortality during a median 25 years follow-up. After adjusting for multiple confounding variables, each one-unit increase in the TyG index was associated with a 96% higher CVD risk (hazard ratio [HR] 1.96, 95% confidence interval [CI] 1.44–2.66) and a 85% higher all-cause mortality risk (HR 1.85, 95% CI 1.45–2.36). Three distinct trajectories of the TyG index along the follow-up duration were identified: low (44.0%), moderate (45.5%), and high (10.5%). Compared with those participants in the low TyG index trajectory group, those in the high TyG index trajectory group had a greater risk of CVD events (HR 2.35, 95% CI 1.34–4.12) and all-cause mortality (HR 3.04, 95% CI 1.83–5.07). The addition of baseline TyG index to pooled cohort equations for CVD improved the C-statistics (P < 0.001), integrated discrimination improvement value (P < 0.001), and category-free net reclassification improvement value (P = 0.003).ConclusionsHigher baseline TyG index levels and higher long-term trajectory of TyG index during young adulthood were significantly associated with an increased risk of incident CVD events and all-cause mortality in later life.
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影响因子：
9.3
作者：
Miao M;Zhou G;Bao A;Sun Y;Du H;Song L;Cao Y;You S;Zhong C
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影响因子：
9.3
作者：
Gao JW;Hao QY;Gao M;Zhang K;Li XZ;Wang JF;Vuitton DA;Zhang SL;Liu PM
通讯作者：
Liu PM
影响因子：
9.3
作者：
通讯作者：
--
DOI：
10.1097/00008483-198911000-00003
发表时间：
1989-11-01
期刊：
Journal of cardiopulmonary rehabilitation
影响因子：
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作者：
Jacobs, David R Jr;Hahn, Lorraine P;Sidney, Stephen
通讯作者：
Sidney, Stephen
影响因子：
3.6
作者：
Liu XC;He GD;Lo K;Huang YQ;Feng YQ
通讯作者：
Feng YQ