Use of naltrexone to treat opioid addiction in a country in which methadone and buprenorphine are not available.
Use of naltrexone to treat opioid addiction in a country in which methadone and buprenorphine are not available.
复制标题
DOI：
10.1007/s11920-010-0135-5
复制
发表时间：
2010-10
影响因子：
6.7
通讯作者：
Woody, George
中科院分区：
文献类型：
--
作者：
Krupitsky, Evgeny;Zvartau, Edwin;Woody, George
阿片类药物依赖是最严重的药物依赖之一。纳洛酮是一种完全阻断阿片类药物的主观和其他影响的药物，当给予脱毒的阿片类药物成瘾者并按指示服用时，可防止复发并有助于保持戒断。纳洛酮的主要问题是依从性差，特别是在存在以口服类阿片激动剂（美沙酮）或部分激动剂/拮抗剂（丁丙诺啡）替代海洛因等非法类阿片的替代治疗方法的国家。在俄罗斯，法律禁止替代疗法，纳洛酮是海洛因依赖的唯一可用药物疗法。由于缺乏纳洛酮的替代品和更强的家庭依从性控制（依从性），纳洛酮在俄罗斯的复发预防和禁欲稳定比西方国家更有效。与口服制剂相比，长效缓释制剂（注射和植入）似乎特别有效。本文总结了在俄罗斯进行的研究，在过去的10年中，证明这些点的结果。
Opioid dependence is one of the most severe drug dependencies. Naltrexone is a medication that completely blocks the subjective and other effects of opioids and, when administered to detoxified opioid addicts and taken as directed, prevents relapse and helps maintain abstinence. The major problem with naltrexone is poor compliance, particularly in countries in which there is a treatment alternative based on substitution of illicit opioids such as heroin with orally administered opioid agonists (methadone) or partial agonist/antagonists (buprenorphine). In Russia, substitution therapy is forbidden by law, and naltrexone is the only available pharmacotherapy for heroin dependence. Due to the lack of alternatives to naltrexone and stronger family control of compliance (adherence), naltrexone is more effective for relapse prevention and abstinence stabilization in Russia than in Western countries. Long-acting, sustained-release formulations (injectable and implantable) seem particularly effective compared with oral formulations. This article summarizes the results of studies conducted in Russia during the past 10 years that demonstrate these points.
登录
查看更多内容
影响因子：
--
作者：
Carroll, KM;Ball, SA;Rounsaville, BJ
通讯作者：
Rounsaville, BJ
影响因子：
3.9
作者：
Krupitsky, EM;Zvartau, EE;Woody, GE
通讯作者：
Woody, GE
DOI：
10.1111/j.1530-0277.2006.00052.x
发表时间：
2006-03-01
影响因子：
3.2
作者：
Dunbar, JL;Turncliff, RZ;Lasseter, KC
通讯作者：
Lasseter, KC
影响因子：
6
作者：
Fishman, Marc
通讯作者：
Fishman, Marc
影响因子：
--
作者：
Hulse, Gary K.;Morris, Noella;Tait, Robert J.
通讯作者：
Tait, Robert J.