COVID-19: Implications for People with Chagas Disease.

COVID-19: Implications for People with Chagas Disease.
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DOI:
10.5334/gh.891
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发表时间:
2020-10-13
期刊:
影响因子:
3.7
通讯作者:
Sosa-Estani S
Sosa-Estani S
中科院分区:
医学4区
文献类型:
--
作者:
Zaidel EJ;Forsyth CJ;Novick G;Marcus R;Ribeiro ALP;Pinazo MJ;Morillo CA;Echeverría LE;Shikanai-Yasuda MA;Buekens P;Perel P;Meymandi SK;Ralston K;Pinto F;Sosa-Estani S

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随着全球新冠肺炎大流行的推进,它对那些已经因被忽视的热带病而背负沉重负担的弱势人群的影响越来越大。恰加斯病(CD)是一种被忽视的寄生虫感染,特别令人担忧,因为它可能导致心脏、胃肠道和其他并发症,从而增加对新冠肺炎的易感性。由于新冠肺炎对心脏的潜在影响,全球100多万慢性恰加斯病患者需要特别考虑,但这一大流行也影响了对急性或慢性不明原因CD患者的治疗。在这份文件中,作为世界卫生基金会-国际ASC CD路线图的后续行动,我们评估了CD的病原体--SARS-CoV-2和克氏锥虫混合感染的影响。基于现有的有限证据,我们为受这两种疾病影响的患者的测试、治疗和管理提供初步指导,同时强调新出现的医疗保健获取挑战和未来的研究需求。
As the global COVID-19 pandemic advances, it increasingly impacts those vulnerable populations who already bear a heavy burden of neglected tropical disease. Chagas disease (CD), a neglected parasitic infection, is of particular concern because of its potential to cause cardiac, gastrointestinal, and other complications which could increase susceptibility to COVID-19. The over one million people worldwide with chronic Chagas cardiomyopathy require special consideration because of COVID-19’s potential impact on the heart, yet the pandemic also affects treatment provision to people with acute or chronic indeterminate CD. In this document, a follow-up to the WHF-IASC Roadmap on CD, we assess the implications of coinfection with SARS-CoV-2 and Trypanosoma cruzi, the etiological agent of CD. Based on the limited evidence available, we provide preliminary guidance for testing, treatment, and management of patients affected by both diseases, while highlighting emerging healthcare access challenges and future research needs.
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